Document Detail

Intrapericardial IGF-I improves cardiac function in an ovine model of chronic heart failure.
MedLine Citation:
PMID:  16352263     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Following myocardial infarction, progressive deterioration of left ventricular function often follows, leading eventually to overt heart failure. In the myocardium, there is increased expression of insulin-like growth factor I (IGF-I) mRNA, protein and receptor levels, particularly in the peri-infarct zone, suggesting that IGF-I has a role to play in post-infarct cardiac structure and function. In this study, we examine the effects of exogenous IGF-I on cardiac function. METHODS: Intrapericardial IGF-I (15 microg/kg/d, n=3) or vehicle (sterile saline, n=3) was administered to sheep in chronic heart failure and the results of intrapericardial delivery compared with those of subcutaneous delivery. Left ventricular ejection fraction (EF) was measured to assess cardiac performance. Concentrations of plasma IGF-I were quantified by radioimmunoassay. RESULTS: Intrapericardial delivery of IGF-I resulted in a rapid and sustained increase (P<0.001) in EF, which remained elevated 14 days after cessation of treatment. Subcutaneous IGF-I treatment did not affect EF. Both subcutaneous and intrapericardial IGF-I administration increased concentrations of plasma IGF-I, although concentrations declined prior to the cessation of treatment. CONCLUSIONS: We conclude that the higher concentration of IGF-I in the myocardium, which results from intrapericardial delivery significantly increases EF in chronic heart failure but that subcutaneous delivery of IGF-I does not.
Kenneth G Matthews; Gerard P Devlin; Selwyn P Stuart; Juliet A Jensen; Robert N Doughty; John V Conaglen; James J Bass
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart, lung & circulation     Volume:  14     ISSN:  1443-9506     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Functional Muscle Genomics Group, AgResearch Ruakura, East Street, Hamilton, New Zealand.
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MeSH Terms
Administration, Cutaneous
Disease Models, Animal
Heart Catheterization
Heart Failure / drug therapy*
Insulin-Like Growth Factor I / administration & dosage*
Myocardium / metabolism
Random Allocation
Stroke Volume / drug effects
Ventricular Function, Left / drug effects*
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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