Document Detail

Intraosseous epithelioid hemangioendothelioma of the mandible: a case report with an immunohistochemical study.
MedLine Citation:
PMID:  10226947     Owner:  NLM     Status:  MEDLINE    
Epithelioid hemangioma is the prototype of a group of vascular tumors characterized by epithelioid endothelial cells. Hemangioendothelioma of bone is a rare lesion that constitutes less than 0.5% of primary malignant skeletal tumors. We report and discuss a case of epithelioid hemangioendothelioma arising intraosseously in the anterior portion of the mandible in a 76-year-old woman. The case was treated successfully by wide resection. Radiographically, the tumor mass showed osteolysis and expansion. Histologically, the tumor showed invasive and destructive growth, although it lacked frequent mitotic figures and severe atypia. On immunohistochemical study, tumor cells exhibited characteristics of mesenchymal and endothelial origin, i.e., strong to moderate immune reactivity against vimentin, factor VIII-related antigen (F8RA), Ulex europaeus agglutinin type 1 lectin (UEA-1), and CD 34, but not against keratin, epithelial membrane antigen (EMA) or S-100 protein (S100). The proliferating cell nuclear antigen (PCNA)-positive cell index was 27.5%. These pathological findings suggested a borderline malignant potential for this tumor. Thus, clinically, wide resection with or without dissection of regional lymph nodes is recommended.
H Hamakawa; T Omori; T Sumida; H Tanioka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  28     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-08     Completed Date:  1999-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Japan.
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MeSH Terms
Antigens, CD34 / analysis
Hemangioendothelioma, Epithelioid / chemistry,  pathology*,  surgery
Lectins / analysis
Mandibular Neoplasms / chemistry,  pathology*,  surgery
Neoplasm Invasiveness
Neoplasm Proteins / analysis
Neoplasms, Vascular Tissue / chemistry,  pathology*,  surgery
Plant Lectins*
Vimentin / analysis
von Willebrand Factor / analysis
Reg. No./Substance:
0/Antigens, CD34; 0/Lectins; 0/Neoplasm Proteins; 0/Plant Lectins; 0/Ulex europaeus lectins; 0/Vimentin; 0/von Willebrand Factor

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