Document Detail

Intraoperative vital and haemodynamic monitoring using an integrated multiple-channel monitor in rats.
MedLine Citation:
PMID:  20150209     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to give a hands-on description of the successful monitoring procedure established for extended liver resections and liver transplantations in rats and to provide the typical range of data as obtained before and after a hepatobiliary surgical procedure (right median hepatic vein [RMHV] ligation) in healthy male Lewis rats. All manipulations were performed in anaesthetized (3% isoflurane in O(2) 1 L/min) healthy male Lewis rats (250-350 g) with an integrated multiple-channel intraoperative monitor (Powerlab system) using a series of sensors for data acquisition. Vital parameters (body temperature, electrocardiogram, respiratory rate and heart rate), haemodynamic parameters (mean arterial blood pressure [MAP] and central venous pressure) and liver perfusion parameters (inferior hepatic venous pressure, portal vein pressure [PVP], blood flow of portal vein and inferior hepatic cava) were monitored. Catheters were placed in microsurgical technique after careful exposure guided by anatomical landmarks. Vascular incisions were closed with interrupted sutures. Complete instrumentation of animals was performed within 1 h. No specific complications occurred. Vital and haemodynamic parameters such as MAP (94 +/- 16.2 mmHg) or portal pressure (9.6 +/- 1.34 mmHg) were in the same range as known for humans (MAP = 100 mmHg, portal pressure = 5-10 mmHg), whereas parameters dependent on the size of the body or organ such as flow rates (portal blood flow = 16.2 +/- 6 mL/min) were obviously different compared with those of humans (portal blood flow = 800 mL/min). In conclusion, the normal range for vital, haemodynamic and liver perfusion parameters was reported as reference values to allow quality control for future surgical hepatobiliary research projects. As the procedure can be easily learned, the extensive intraoperative monitoring can be used routinely.
Hai Huang; Meihong Deng; Hao Jin; Olaf Dirsch; Uta Dahmen
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Publication Detail:
Type:  Journal Article     Date:  2010-02-11
Journal Detail:
Title:  Laboratory animals     Volume:  44     ISSN:  1758-1117     ISO Abbreviation:  Lab. Anim.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-63     Citation Subset:  IM    
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
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MeSH Terms
Biliary Tract Surgical Procedures / veterinary
Blood Pressure Monitors / veterinary
Hemodynamics / physiology*
Hepatectomy / veterinary
Liver / surgery
Liver Circulation / physiology*
Liver Transplantation / physiology,  veterinary
Monitoring, Intraoperative / instrumentation,  veterinary*
Rats, Inbred Lew

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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