| Intraoperative thrombolysis in peripheral arterial occlusion. | |
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MedLine Citation:
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PMID: 8370017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thromboembolic occlusion of peripheral arteries continues to be associated with significant morbidity, mortality and loss of limbs. Surgical intervention with prompt revascularization by clot extraction, alone or in combination with arterial bypass, remains the standard therapy for critical ischemia with imminent tissue loss. Mechanical thrombectomy using a balloon catheter has been the preferred technique for distal embolus or thrombus extraction. Unfortunately, complete thrombectomy is rare, and the procedure is associated with arterial wall injury. Intraoperative thrombolytic therapy is an attractive adjunct to catheter thrombectomy alone and is appropriate in the care of a significant number of patients with acute limb ischemia. Its safety and efficacy have been confirmed in the laboratory and in a limited number of patients. The authors review experimental and clinical data and report their experience with 19 patients. |
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Authors:
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J A Wasselle; D F Bandyk |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 36 ISSN: 0008-428X ISO Abbreviation: Can J Surg Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-10-14 Completed Date: 1993-10-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: CANADA |
Other Details:
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Languages: eng Pagination: 354-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of South Florida College of Medicine, Tampa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amputation / statistics & numerical data Angiography Angioplasty, Balloon Arterial Occlusive Diseases / drug therapy*, radiography Clinical Trials as Topic Combined Modality Therapy Disease Models, Animal Drug Evaluation Hemorrhage / chemically induced, epidemiology Humans Intraoperative Care / methods* Peripheral Vascular Diseases / drug therapy*, radiography Postoperative Complications / chemically induced, epidemiology Prognosis Streptokinase / pharmacology, therapeutic use* Thrombectomy Thromboembolism / drug therapy*, radiography Thrombolytic Therapy / adverse effects, methods* Tissue Plasminogen Activator / pharmacology, therapeutic use* Treatment Outcome Urokinase-Type Plasminogen Activator / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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