Document Detail


Intraoperative thrombolysis in peripheral arterial occlusion.
MedLine Citation:
PMID:  8370017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thromboembolic occlusion of peripheral arteries continues to be associated with significant morbidity, mortality and loss of limbs. Surgical intervention with prompt revascularization by clot extraction, alone or in combination with arterial bypass, remains the standard therapy for critical ischemia with imminent tissue loss. Mechanical thrombectomy using a balloon catheter has been the preferred technique for distal embolus or thrombus extraction. Unfortunately, complete thrombectomy is rare, and the procedure is associated with arterial wall injury. Intraoperative thrombolytic therapy is an attractive adjunct to catheter thrombectomy alone and is appropriate in the care of a significant number of patients with acute limb ischemia. Its safety and efficacy have been confirmed in the laboratory and in a limited number of patients. The authors review experimental and clinical data and report their experience with 19 patients.
Authors:
J A Wasselle; D F Bandyk
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  36     ISSN:  0008-428X     ISO Abbreviation:  Can J Surg     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of South Florida College of Medicine, Tampa.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amputation / statistics & numerical data
Angiography
Angioplasty, Balloon
Arterial Occlusive Diseases / drug therapy*,  radiography
Clinical Trials as Topic
Combined Modality Therapy
Disease Models, Animal
Drug Evaluation
Hemorrhage / chemically induced,  epidemiology
Humans
Intraoperative Care / methods*
Peripheral Vascular Diseases / drug therapy*,  radiography
Postoperative Complications / chemically induced,  epidemiology
Prognosis
Streptokinase / pharmacology,  therapeutic use*
Thrombectomy
Thromboembolism / drug therapy*,  radiography
Thrombolytic Therapy / adverse effects,  methods*
Tissue Plasminogen Activator / pharmacology,  therapeutic use*
Treatment Outcome
Urokinase-Type Plasminogen Activator / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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