| Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinoma. | |
| | |
MedLine Citation:
|
PMID: 10215818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Orderly progression of nodal metastases has been described for melanoma and breast cancer. The first draining lymph node, the sentinel node, is also the first to contain metastases and accurately predicts nodal status. The aim of this study was to assess the feasibility of lymphatic mapping and sentinel node biopsy in colorectal cancer. METHODS: In 50 patients with colorectal cancer patent blue dye was injected around the tumour. After resection of the tumour the specimen was examined to identify blue-stained lymph nodes. Routine histopathological examination was performed on all nodes and the blue, haematoxylin and eosin-stained tumour-negative nodes were tested immunohistochemically. RESULTS: Lymphatic mapping was possible in 35 of 50 patients (70 per cent). Pathological examination with haematoxylin and eosin staining showed lymph node metastases in 20 of 35 patients. In eight of these 20 patients the blue nodes showed tumour, while in 12 the blue nodes were not involved. This represents a false-negative rate of 60 per cent. CONCLUSION: Lymphatic mapping using patent blue dye is feasible in colorectal cancer. The blue-stained nodes do not predict nodal status of the remaining lymph nodes in the resected specimen. The concept of lymphatic mapping and sentinel node identification is not valid for colorectal cancer. |
| | |
Authors:
|
J J Joosten; L J Strobbe; C A Wauters; M Pruszczynski; T Wobbes; T J Ruers |
Related Documents
:
|
19223378 - Intraoperative consultation for axillary sentinel lymph node biopsy: an 8-year audit. 20347308 - Accurate classification of sentinel lymph node metastases in patients with lobular brea... 11140878 - Future perspectives on selective sentinel lymphadenectomy. 11702098 - An original approach in the diagnosis of early breast cancer: use of the same radiophar... 9164268 - Perspectives on integrating experimental and epidemiologic research on diet, anthropome... 11433618 - Assessment of radical prostatectomy specimens and diagnostic reporting of pathological ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The British journal of surgery Volume: 86 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1999 Apr |
Date Detail:
|
Created Date: 1999-05-17 Completed Date: 1999-05-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 482-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
secondary* Biopsy / methods* Colonic Neoplasms / pathology* Humans Immunohistochemistry Intraoperative Care Lymph Nodes / pathology Lymphatic Metastasis / pathology* Rectal Neoplasms / pathology* |
| Comments/Corrections | |
Comment In:
|
Br J Surg. 1999 Sep;86(9):1225-6
[PMID:
10576902
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of volume of work on the outcome of treatment for patients with colorectal cancer.
Next Document: Lateral ligaments of the rectum: an anatomical study.