Document Detail


Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinoma.
MedLine Citation:
PMID:  10215818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Orderly progression of nodal metastases has been described for melanoma and breast cancer. The first draining lymph node, the sentinel node, is also the first to contain metastases and accurately predicts nodal status. The aim of this study was to assess the feasibility of lymphatic mapping and sentinel node biopsy in colorectal cancer. METHODS: In 50 patients with colorectal cancer patent blue dye was injected around the tumour. After resection of the tumour the specimen was examined to identify blue-stained lymph nodes. Routine histopathological examination was performed on all nodes and the blue, haematoxylin and eosin-stained tumour-negative nodes were tested immunohistochemically. RESULTS: Lymphatic mapping was possible in 35 of 50 patients (70 per cent). Pathological examination with haematoxylin and eosin staining showed lymph node metastases in 20 of 35 patients. In eight of these 20 patients the blue nodes showed tumour, while in 12 the blue nodes were not involved. This represents a false-negative rate of 60 per cent. CONCLUSION: Lymphatic mapping using patent blue dye is feasible in colorectal cancer. The blue-stained nodes do not predict nodal status of the remaining lymph nodes in the resected specimen. The concept of lymphatic mapping and sentinel node identification is not valid for colorectal cancer.
Authors:
J J Joosten; L J Strobbe; C A Wauters; M Pruszczynski; T Wobbes; T J Ruers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  86     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  482-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / secondary*
Biopsy / methods*
Colonic Neoplasms / pathology*
Humans
Immunohistochemistry
Intraoperative Care
Lymph Nodes / pathology
Lymphatic Metastasis / pathology*
Rectal Neoplasms / pathology*
Comments/Corrections
Comment In:
Br J Surg. 1999 Sep;86(9):1225-6   [PMID:  10576902 ]

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