Document Detail

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men.
MedLine Citation:
PMID:  22986318     Owner:  NLM     Status:  In-Data-Review    
STUDY OBJECTIVE: To evaluate whether intraoperative low-dose lidocaine infusion decreases postoperative analgesic consumption, ileus, and duration of hospital stay.
DESIGN: Prospective, randomized, double-blinded trial.
SETTING: Operating room in a university hospital.
PATIENTS: 48 ASA physical status 1 and 2 men scheduled for subtotal gastrectomy.
INTERVENTIONS: Patients were randomly allocated to two groups to receive either intravenous (IV) lidocaine 1.5 mg/kg 20 minutes before incision followed by a continuous lidocaine infusion of 1.5 mg/kg/hr until the end of surgery (lidocaine group) or saline in a similar manner (control group).
MEASUREMENTS: Outcomes such as pain intensity, postoperative analgesic consumption, duration of ileus, and hospital length of stay (LOS) were recorded.
MAIN RESULTS: There were no differences in total consumption of IV patient-controlled analgesia (IVPCA) or pain scores at 24, 48, or 72 hours postoperatively. However, lidocaine group patients had significantly decreased average supplemental pethidine requirement per patient for pain control until 72 hours postoperatively [150 (75-200) mg vs 50 (50-150) mg, P = 0.039] and hospital LOS (9.5 ± 3 d vs 8.7 ± 1 d, P = 0.006, 95% CI: - 0.3 - 1.9 d) than control group patients. However, no differences were noted between the groups in pain intensity or duration of ileus.
CONCLUSIONS: Intraoperative IV low-dose lidocaine infusion decreased opioid consumption and hospital LOS after gastrectomy.
Jin Gu Kang; Myung Hee Kim; Eun Hee Kim; Sang Hyun Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  24     ISSN:  1873-4529     ISO Abbreviation:  J Clin Anesth     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul, Korea.
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