Document Detail

Intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery.
MedLine Citation:
PMID:  10321528     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Postoperative recurrence of pterygium occurs in many patients. Intraoperative and postoperative mitomycin therapy are two adjuvant treatment methods shown to lessen the high pterygium recurrence rate seen with simple excision alone. The authors designed a prospective, randomized study to explore the recurrence rate of pterygium after a single dosage of mitomycin C at the completion of pterygium excision, comparing it to postoperative mitomycin C therapy. METHODS: Thirty-six patients with 40 primary and recurrent pterygia were randomized to 1 of 2 treatment groups: intraoperative mitomycin 0.2 mg/ml for 5 minutes (group 1) and postoperative mitomycin 0.2 mg/ml four times a day for 7 days (group 2). The mean follow-up time was 15 months (range, 6 to 24 months). RESULTS: The pterygium recurred in 3 (15%) of 20 eyes in group 1 and in 4 (20%) of 20 eyes in group 2 (p=0.41). One patient in group 1 had a mild scleral melting (1 x 1 mm) and a delay of reepithelialization for three weeks. Moderate superficial punctate keratitis (two eyes) and mild anterior chamber reaction (one eye) developed in group 2. CONCLUSION: This study indicates possible advantages of administration of a single dosage of 0.02% mitomycin C over postoperative mitomycin therapy. If the decision is made to use adjunctive mitomycin, the authors recommend intraoperative over postoperative administration.
H Oguz; E Basar; B Gurler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  77     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Department of Ophthalmology, University of Harran, School of Medicine, Sanliurfa, Turkey.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage*
Chemotherapy, Adjuvant
Follow-Up Studies
Intraoperative Care / methods*
Middle Aged
Mitomycin / administration & dosage*
Ophthalmic Solutions / administration & dosage
Postoperative Care / methods*
Prospective Studies
Pterygium / drug therapy*,  etiology,  surgery
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Ophthalmic Solutions; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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