Document Detail

Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report.
MedLine Citation:
PMID:  23021035     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND CONTEXT: The use of topical hemostatic agents is widespread and has been shown to reduce bleeding during a wide variety of surgical procedures. Nonetheless, as biologically active agents, there is potential for allergic reactions to these products.
PURPOSE: This is a report of intraoperative anaphylaxis to gelatin associated with the use of two topical hemostatic agents.
STUDY DESIGN: Case report. There is no outside funding or potential conflict of interest.
PATIENT SAMPLE: A patient with anaphylaxis during anterior spinal fusion.
OUTCOME MEASURES: Laboratory assays for tryptase, gelatin-specific immunoglobulin E (IgE), and total IgE.
METHODS: A 14-year-old male with myelomeningocele and scoliosis was treated with anterior spinal fusion from T12 to L3. Gelfoam sponges were applied during the preparation of the disc spaces. Approximately 1 hour later, Floseal hemostatic matrix was applied to a briskly bleeding screw hole in the L3 vertebral body, and the patient experienced an abrupt onset of hypotension and ventilatory difficulty. Epinephrine, dexamethasone, and blood products were administered for hemodynamic support while the surgical site was closed. Removal of the drapes revealed a widespread erythematous rash, and the patient was then transferred to the intensive care unit. When stable 3 days later, he returned to the operating room for completion of the spinal fusion.
RESULTS: Postoperative laboratory assays were sent that revealed elevated levels of tryptase, total IgE, porcine, and bovine gelatin-specific IgE. The patient was counseled to avoid gelatin-containing products. At 6-month follow-up, his instrumented spine was radiographically fused and he reported no further allergic issues.
CONCLUSIONS: Anaphylaxis may occur because of animal gelatin components of topical hemostatic agents. Previous reports have focused on the thrombin components. Care should be taken in the administration of these products, particularly in the atopic individual.
Hillard T Spencer; Joyce T Hsu; Douglas R McDonald; Lawrence I Karlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The spine journal : official journal of the North American Spine Society     Volume:  12     ISSN:  1878-1632     ISO Abbreviation:  Spine J     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130732     Medline TA:  Spine J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Orthopaedic Surgery, Children's Hospital Boston, 300 Longwood Ave., Hunnewell 221, Boston, MA 02115, USA. Electronic address:
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