Document Detail

Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effects in healthy weight and obese patients undergoing laparoscopy.
MedLine Citation:
PMID:  21068660     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary function is impaired during pneumoperitoneum mainly as a result of atelectasis formation. We studied the effects of 10 cm H2O of positive end-expiratory pressure (PEEP) and PEEP followed by a recruitment maneuver (PEEP+RM) on end-expiratory lung volume (EELV), oxygenation and respiratory mechanics in patients undergoing laparoscopic surgery.
METHODS: Sixty consecutive adult patients (30 obese, 30 healthy weight) in reverse Trendelenburg position were prospectively studied. EELV, static elastance of the respiratory system, dead space, and gas exchange were measured before and after pneumoperitoneum insufflation with zero end-expiratory pressure, with PEEP alone, and with PEEP+RM. Results are presented as mean ± SD.
RESULTS: Pneumoperitoneum reduced EELV (healthy weight, 1195 ± 405 vs. 1724 ± 774 ml; obese, 751 ± 258 vs. 886 ± 284 ml) and worsened static elastance and dead space in both groups (in all P < 0.01 vs. zero-end expiratory pressure before pneumoperitoneum) whereas oxygenation was unaffected. PEEP increased EELV (healthy weight, 570 ml, P < 0.01; obese, 364 ml, P < 0.01) with no effect on oxygenation. Compared with PEEP alone, EELV and static elastance were further improved after RM in both groups (P < 0.05), as was oxygenation (P < 0.01). In all patients, RM-induced change in EELV was 16% (P = 0.04). These improvements were maintained 30 min after RM. RM-induced changes in EELV correlated with change in oxygenation (r = 0.42, P < 0.01).
CONCLUSION: RM combined with 10 cm H2O of PEEP improved EELV, respiratory mechanics, and oxygenation during pneumoperitoneum whereas PEEP alone did not.
Emmanuel Futier; Jean-Michel Constantin; Paolo Pelosi; Gerald Chanques; Fabrice Kwiatkoskwi; Samir Jaber; Jean-Etienne Bazin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  113     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1310-9     Citation Subset:  AIM; IM    
Department of Anesthesiology and Critical Care Medicine, Estaing Hospital, Clermont-Ferrand, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, General
Body Weight / physiology
Expiratory Reserve Volume / physiology
Hemodynamics / physiology
Intraoperative Complications / therapy*
Lung Volume Measurements
Middle Aged
Obesity / complications,  physiopathology*
Oxygen Consumption / physiology
Pneumoperitoneum, Artificial / adverse effects*
Positive-Pressure Respiration
Pulmonary Gas Exchange / physiology
Respiratory Dead Space / physiology
Respiratory Mechanics / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of a comprehensive safety initiative on patient-controlled analgesia errors.
Next Document:  Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response ...