Document Detail


Intraoperative Mitomycin C for Nonpenetrating Glaucoma Surgery: A Systematic Review and Meta-analysis.
MedLine Citation:
PMID:  20577107     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy and tolerability between nonpenetrating glaucoma surgery with (NPGS-MMC) and without (NPGS-noMMC) intraoperative mitomycin C application in the treatment of patients with open angle glaucoma.
METHODS: Pertinent studies were selected through extensive searches of the Cochrane Library, PubMed, Embase, and Chinese Biomedicine Database. Eight controlled clinical trials meeting the predefined criteria were systematically reviewed by meta-analysis. The main outcome measures were percentage intraocular pressure reduction and complete success rate. The pooled estimates were carried out in RevMan version 5.0 software.
RESULTS: The weighted mean differences of the percentage intraocular pressure reduction when comparing NPGS-MMC with NPGS-noMMC were 5.24% (95% confidence intervals: -3.24-13.72) at 6 months, 8.31% (4.33 to 12.30) at 12 months, 9.56% (4.88 to 14.24) at 24 months, and 14.45% (9.03 to 19.88) at 36 months. NPGS-MMC was associated with significant greater complete success rates compared with NPGS-noMMC, with a pooled risk ratio being 1.16 (1.05 to 1.27) at 6 months, 1.20 (1.05 to 1.38) at 12 months, 1.30 (1.05 to 1.61) at 24 months, and 1.36 (1.06 to 1.73) at 36 months. Intraoperative MMC was not associated with any drug-induced complications.
CONCLUSIONS: The use of intraoperative MMC is a safe and effective additional step during nonpenetrating filtering surgery.
Authors:
Jin-Wei Cheng; Ji-Ping Cai; You Li; Rui-Li Wei
Related Documents :
24616807 - Does duration of preoperative sciatica impact surgical outcomes in patients with lumbar...
17141317 - Narrow-strip conjunctival autograft for treatment of pterygium.
17291337 - Heavier molecular weight ocular viscoelastic devices and timing of post-operative revie...
18347627 - Finger massage versus a novel massage device after trabeculectomy.
6371647 - Eyelid and orbital treatment following radical maxillectomy.
22149147 - Systematic evaluation of a novel foot-pump ureteroscopic irrigation system.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  20     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2011 Jun-Jul
Date Detail:
Created Date:  2011-06-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circumferential Viscocanalostomy and Suture Canal Distension (Canaloplasty) for Whites With Open-ang...
Next Document:  Comparison of the prevalence of plateau iris configurations between angle-closure glaucoma and open-...