Document Detail

Intraoperative Electron Radiotherapy (IOERT) as an Alternative to Standard Whole Breast Irradiation: Only for Low-Risk Subgroups?
MedLine Citation:
PMID:  24944552     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Intraoperative radiotherapy during breast-conserving surgery is being studied as an alternative to 6 weeks of external beam radiotherapy (EBRT) for low-risk women; it can be delivered using electrons (intraoperative electron radiotherapy, IOERT) or 50-kV X-rays.
MATERIALS AND METHODS: We analyzed both single institutional and randomized studies involving single-fraction IOERT treatments. Rates for ipsilateral breast tumor recurrences, disease-specific survival, and overall survival were obtained.
RESULTS: IOERT had true 5-year recurrence rates of > 1.5% for ASTRO (American Society for Radiation Oncology) and ESTRO (European Society for Therapeutic Radiology and Oncology) suitable women, or for low-risk women as defined by the ELIOT trial. Women with ductal carcinoma in situ eligible for breast-conserving therapy, older women that currently receive no EBRT, and younger women with favorable biology are additional potential candidates.
CONCLUSION: ASTRO suitable and ESTRO good women for accelerated partial breast irradiation are low-risk groups. Higher-risk women with favorable biology might also be suitable candidates for IOERT, providing the tumor biology can be determined prior to surgery. For intraoperative radiotherapy using 50-kV X-rays, follow-up was too short to assess the effectiveness of the treatment.
Sergio Maluta; Stefano Dall'Oglio; Donald A Goer; Nadia Marciai
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Breast care (Basel, Switzerland)     Volume:  9     ISSN:  1661-3791     ISO Abbreviation:  Breast Care (Basel)     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-06-19     Completed Date:  2014-06-24     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101254060     Medline TA:  Breast Care (Basel)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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