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Intraoperative Detection of Ganglioneuromas With 123I-MIBG.
MedLine Citation:
PMID:  22785506     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT: Radioactive MIBG can be used in radioguided surgery for neuroendocrine tumors. We report the case of a man with a mutation in the succinate dehydrogenase subunit B (SDHB) gene, in which an abdominal MRI scan identified two 5-mm left para-aortic nodules, suspect for paragangliomas. Subsequent SPECT revealed increased uptake of tracer. I MIBG probe-guided resection was scheduled. During surgery, 2 small nodules with elevated activity in between the superior mesenteric artery and the left adrenal gland were identified by the detection probe and were resected. Histopathologic examination revealed mature ganglioneuromas.
Authors:
Leonie Theresia van Hulsteijn; Bernies van der Hiel; Jan W A Smit; Marcel P Stokkel; Eleonora P M Corssmit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  768-71     Citation Subset:  IM    
Affiliation:
From the Departments of *Endocrinology and Metabolic Diseases and †Nuclear Medicine, Leiden University Medical Center, Leiden; and ‡Department of Nuclear Medicine, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
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