| Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study. | |
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MedLine Citation:
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PMID: 17109155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema due to central retinal vein occlusion (CRVO). A noncomparative, prospective, interventional case series. METHODS: In this study 15 eyes of 15 patients (9 males and 6 females) with macular edema due to non-ischemic CRVO were treated with intravitreal injection of 4 mg triamcinolone acetonide and followed-up for 1 year. Examination included measurement of best-corrected visual acuity (BCVA) for distance, measurement of intraocular pressure (IOP), fluorescein angiography, foveal retinal thickness measurement by optical coherence tomography (OCT), and multifocal electroretinography recordings (MFERG) preoperatively 3, 6 and 12 months postoperatively. RESULTS: The visual acuity increased to a significant degree at 3 months, to a smaller degree at 6 months but at 12 months there was no significant improvement. The OCT macula thickness improved to a significant level all the follow-up period but with less significance at 12 months. The MFERG recordings from the fovea showed significant improvement at 3 and 6 months. The MFERG from the parafovea area showed significant improvement at 3 and 6 and to a smaller degree at 12 months. The intraocular pressure increased at 3 and 6 months but returned to pretreatment level at 12 months. CONCLUSION: Intravitreal injection of triamcinolone acetonide leads to a significant improvement of mean VA in patients with macular edema due to CRVO. However, this significant effect is not permanent and persists for a maximum of 3-6 months. Thereafter all the indexes tend to deteriorate. |
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Authors:
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Marilita M Moschos; Dimitrios Brouzas; Eleni Loukianou; Michael Apostolopoulos; Michael Moschos |
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Publication Detail:
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Type: Journal Article Date: 2006-11-16 |
Journal Detail:
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Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 114 ISSN: 0012-4486 ISO Abbreviation: Doc Ophthalmol Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-31 Completed Date: 2007-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Athens, Athens, Greece. moschosmarilita@yahoo.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Electroretinography / methods* Female Follow-Up Studies Glucocorticoids / administration & dosage* Humans Injections Macular Edema / diagnosis, drug therapy*, etiology Male Middle Aged Retinal Vein Occlusion / complications*, diagnosis Tomography, Optical Coherence / methods* Treatment Outcome Triamcinolone Acetonide / administration & dosage* Visual Acuity Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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