Document Detail


Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study.
MedLine Citation:
PMID:  17109155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema due to central retinal vein occlusion (CRVO). A noncomparative, prospective, interventional case series. METHODS: In this study 15 eyes of 15 patients (9 males and 6 females) with macular edema due to non-ischemic CRVO were treated with intravitreal injection of 4 mg triamcinolone acetonide and followed-up for 1 year. Examination included measurement of best-corrected visual acuity (BCVA) for distance, measurement of intraocular pressure (IOP), fluorescein angiography, foveal retinal thickness measurement by optical coherence tomography (OCT), and multifocal electroretinography recordings (MFERG) preoperatively 3, 6 and 12 months postoperatively. RESULTS: The visual acuity increased to a significant degree at 3 months, to a smaller degree at 6 months but at 12 months there was no significant improvement. The OCT macula thickness improved to a significant level all the follow-up period but with less significance at 12 months. The MFERG recordings from the fovea showed significant improvement at 3 and 6 months. The MFERG from the parafovea area showed significant improvement at 3 and 6 and to a smaller degree at 12 months. The intraocular pressure increased at 3 and 6 months but returned to pretreatment level at 12 months. CONCLUSION: Intravitreal injection of triamcinolone acetonide leads to a significant improvement of mean VA in patients with macular edema due to CRVO. However, this significant effect is not permanent and persists for a maximum of 3-6 months. Thereafter all the indexes tend to deteriorate.
Authors:
Marilita M Moschos; Dimitrios Brouzas; Eleni Loukianou; Michael Apostolopoulos; Michael Moschos
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Publication Detail:
Type:  Journal Article     Date:  2006-11-16
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  114     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Athens, Athens, Greece. moschosmarilita@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Electroretinography / methods*
Female
Follow-Up Studies
Glucocorticoids / administration & dosage*
Humans
Injections
Macular Edema / diagnosis,  drug therapy*,  etiology
Male
Middle Aged
Retinal Vein Occlusion / complications*,  diagnosis
Tomography, Optical Coherence / methods*
Treatment Outcome
Triamcinolone Acetonide / administration & dosage*
Visual Acuity
Vitreous Body
Chemical
Reg. No./Substance:
0/Glucocorticoids; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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