Document Detail

Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas.
MedLine Citation:
PMID:  12770969     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the correlation between visual field loss and the pretreatment intraocular pressure (IOP) in primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG). METHODS: In a cross sectional observational study of 74 patients (43 PACG, 31 POAG), pretreatment IOP was measured at presentation, before treatment was initiated. The severity of visual field loss was assessed by AGIS score, mean deviation (MD), pattern standard deviation (PSD), and corrected pattern standard deviation (CPSD). Glaucomatous optic neuropathy was assessed from simultaneous stereo disc photographs. RESULTS: There was a stronger correlation between pretreatment IOP and the extent of visual field loss in PACG subjects than in those with POAG for both MD (PACG: Pearson correlation coefficient (r) = 0.43, p = 0.002; r(2) = 0.19), (POAG: r = 0.21, p = 0.13; r(2) = 0.04) and AGIS score (PACG: r = 0.41, p = 0.003; r(2) = 0.17), (POAG: r = 0.23, p = 0.19; r(2) = 0.05 respectively). No such associations were seen for pattern standard deviation (PSD) or corrected pattern standard deviation (CPSD) in either group (p> 0.29). Both horizontal and vertical cup-disc ratio were well correlated with severity of field loss but not with presenting IOP for either diagnosis. CONCLUSIONS: This is consistent with the hypothesis of a greater IOP dependence for optic nerve damage in PACG than POAG and, conversely, a greater importance of other, less pressure dependent mechanisms in POAG compared to PACG.
G Gazzard; P J Foster; J G Devereux; F Oen; P Chew; P T Khaw; S Seah
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  87     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-07-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  720-5     Citation Subset:  IM    
Singapore National Eye Centre, (SNEC), 11 Third Hospital Avenue, Singapore 168751, Republic of Singapore.
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MeSH Terms
Antimetabolites / therapeutic use
Cross-Sectional Studies
Fluorouracil / therapeutic use
Glaucoma, Angle-Closure / complications,  physiopathology*,  surgery
Glaucoma, Open-Angle / complications,  physiopathology*,  surgery
Intraocular Pressure / physiology*
Middle Aged
Prospective Studies
Regression Analysis
Trabeculectomy / methods
Treatment Outcome
Vision Disorders / etiology*
Visual Fields* / physiology
Reg. No./Substance:
0/Antimetabolites; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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