| Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride. | |
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MedLine Citation:
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PMID: 21223530 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Acta Ophthalmol. 2011: 89: e57-e63 ABSTRACT.: Aims: This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (POAG) treated with morning-dosed bimatoprost 0.03%. Methods: Eighty-nine patients (aged, 60.7 ± 11.8 years, range 33-80; 68 women) with POAG received bimatoprost dosed once in the morning for 1 month, after which dorzolamide was added twice daily for 2 months. IOP (Goldmann) and arterial blood pressure (BP) and diurnal ocular perfusion pressures (OPP) were measured every 2 hr for 24 hr. Heidelberg retina flowmetry of the retinal microcirculation was recorded four times daily in 64 patients and colour Doppler imaging of the ophthalmic and central retinal arteries was recorded five times daily in 25 patients. All measurements were taken after the two phases of treatment and compared using anova analysis with Bonferroni adjustment. Results: Mean baseline IOP was 16.5 ± 3.4 mmHg. Mean diurnal IOP with dorzolamide adjunctive therapy (12.9 ± 2.1 mmHg) was significantly lower compared to mean IOP with bimatoprost monotherapy (13.6 ± 2.2 mmHg) (p = 0.03). Adjunctive dorzolamide therapy significantly decreased vascular resistance in the ophthalmic artery (p = 0.02). Mean diastolic BP and OPP were significantly lower after adjunctive therapy. There were no changes in retinal microcirculation between the two phases of treatment. Conclusions: Adjunctive dorzolamide therapy to morning-dosed bimatoprost 0.03% reduced diurnal IOP and vascular resistance in the ophthalmic artery but did not alter retinal circulation in this group of patients with POAG. |
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Authors:
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Andrzej Stankiewicz; Marta Misiuk-Hojło; Iwona Grabska-Liberek; Bożena Romanowska-Dixon; Joanna Wierzbowska; Jaromir Wasyluk; Małgorzata Mulak; Iwona Szuścik; Janusz Sierdziński; Rita Ehrlich; Brent Siesky; Alon Harris |
Publication Detail:
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Type: Journal Article Date: 2011-01-11 |
Journal Detail:
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Title: Acta ophthalmologica Volume: 89 ISSN: 1755-3768 ISO Abbreviation: Acta Ophthalmol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: e57-63 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation. |
Affiliation:
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Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Department of Ophthalmology, Medical University, Wroclaw, Poland Department of Ophthalmology, Medical Center of Postgradual Education, Warsaw, Poland Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University, Cracow, Poland Department of Informatics and Telemedicine, Medical University, Warsaw, Poland Glaucoma Research Center, Indiana University School of Medicine, Indianapolis, USA. |
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