Document Detail


Intraocular pressure in rabbits by telemetry II: effects of animal handling and drugs.
MedLine Citation:
PMID:  9804159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To measure under carefully controlled conditions the effects in the rabbit eye of commonly used therapeutic agents for glaucoma. METHODS: Rabbits were outfitted in one eye with an implantable telemetric pressure transducer and monitored for several months under controlled conditions of light/ dark and handling. Effects of tonometry, handling, water drinking, and instillation of topical ophthalmic medications on intraocular pressure were recorded during each 24-hour day/night cycle. RESULTS: Pneumatonometry, animal handling, and water drinking all had an effect on intraocular pressure that in many instances was of the same magnitude as the effects of pharmacologic agents. Dorzolamide and timolol caused a sustained reduction of intraocular pressure during the nocturnal period. Epinephrine had a biphasic effect, causing an immediate pressure elevation followed by a prolonged depression. Apraclonidine, latanoprost, and pilocarpine had no measurable effect. CONCLUSIONS: Continuous telemetric measurement of intraocular pressure in rabbits permits the measurement of uncontrollable artifacts that occur with tonometric measurements and animal handling. If environmental conditions are rigidly controlled, this method is very sensitive for detecting therapeutic effects of candidates for ocular hypotensive drugs. When healthy animals are used, the method appears to be more sensitive for drugs that affect aqueous humor formation than for drugs that affect aqueous humor outflow resistance.
Authors:
S Dinslage; J McLaren; R Brubaker
Related Documents :
16378009 - Intraocular pressure measurement-comparison of dynamic contour tonometry and goldmann a...
2707039 - Modification and calibration of the bigliano-webb tonometer for improved accuracy of to...
9493779 - Reproducibility of intraocular pressure and outflow facility measured by pneumatic tono...
3987349 - Decreased intraocular pressure and aqueous humor turnover rate during longitudinal ocul...
2612679 - Comparison of a new non-contact tonometer with goldmann applanation.
1781239 - Microfibril-microvessel connections in the uvea and optic nerve of the mammalian eye.
4835509 - Long term results of gastrectomy with respect to blood lipids, blood pressure, weight a...
8919619 - Measurement of dynamic pressures at the shoe-foot interface during normal walking with ...
18695309 - Hepatic venous pressure gradient measurement: time to learn!
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  39     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-09     Completed Date:  1998-11-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2485-9     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animal Husbandry*
Animals
Circadian Rhythm
Clonidine / analogs & derivatives,  pharmacology
Epinephrine / pharmacology
Intraocular Pressure / drug effects*
Ophthalmic Solutions / pharmacology*
Pilocarpine / pharmacology
Prostaglandins F, Synthetic / pharmacology
Rabbits
Sulfonamides / pharmacology
Telemetry / methods*
Thiophenes / pharmacology
Timolol / pharmacology
Tonometry, Ocular / methods*
Grant Support
ID/Acronym/Agency:
EY00634/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiophenes; 130209-82-4/latanoprost; 130693-82-2/dorzolamide; 26839-75-8/Timolol; 4205-90-7/Clonidine; 51-43-4/Epinephrine; 66711-21-5/apraclonidine; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Partial characterization of the human retinal endothelial cell tight and adherens junction complexes...
Next Document:  Characterization of mutations located in exon 18 of the CFTR gene.