Document Detail

Intraocular pressure in rabbits by telemetry II: effects of animal handling and drugs.
MedLine Citation:
PMID:  9804159     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To measure under carefully controlled conditions the effects in the rabbit eye of commonly used therapeutic agents for glaucoma. METHODS: Rabbits were outfitted in one eye with an implantable telemetric pressure transducer and monitored for several months under controlled conditions of light/ dark and handling. Effects of tonometry, handling, water drinking, and instillation of topical ophthalmic medications on intraocular pressure were recorded during each 24-hour day/night cycle. RESULTS: Pneumatonometry, animal handling, and water drinking all had an effect on intraocular pressure that in many instances was of the same magnitude as the effects of pharmacologic agents. Dorzolamide and timolol caused a sustained reduction of intraocular pressure during the nocturnal period. Epinephrine had a biphasic effect, causing an immediate pressure elevation followed by a prolonged depression. Apraclonidine, latanoprost, and pilocarpine had no measurable effect. CONCLUSIONS: Continuous telemetric measurement of intraocular pressure in rabbits permits the measurement of uncontrollable artifacts that occur with tonometric measurements and animal handling. If environmental conditions are rigidly controlled, this method is very sensitive for detecting therapeutic effects of candidates for ocular hypotensive drugs. When healthy animals are used, the method appears to be more sensitive for drugs that affect aqueous humor formation than for drugs that affect aqueous humor outflow resistance.
S Dinslage; J McLaren; R Brubaker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  39     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-09     Completed Date:  1998-11-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2485-9     Citation Subset:  IM    
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
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MeSH Terms
Animal Husbandry*
Circadian Rhythm
Clonidine / analogs & derivatives,  pharmacology
Epinephrine / pharmacology
Intraocular Pressure / drug effects*
Ophthalmic Solutions / pharmacology*
Pilocarpine / pharmacology
Prostaglandins F, Synthetic / pharmacology
Sulfonamides / pharmacology
Telemetry / methods*
Thiophenes / pharmacology
Timolol / pharmacology
Tonometry, Ocular / methods*
Grant Support
Reg. No./Substance:
0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiophenes; 130209-82-4/latanoprost; 130693-82-2/dorzolamide; 26839-75-8/Timolol; 4205-90-7/Clonidine; 51-43-4/Epinephrine; 66711-21-5/apraclonidine; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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