| Intranuclear ubiquitin immunoreactivity in the pigmented neurons of the substantia nigra in fire fatalities. | |
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MedLine Citation:
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PMID: 11508795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the significance of immunohistochemical staining of ubiquitin (heat shock protein) in the midbrain for medico-legal investigation of death in fires, we examined forensic autopsy cases of fire fatalities (n = 35) in comparison with controls (n = 27; brain stem injury, acute myocardial infarction and carbon monoxide poisoning other than fire fatality). There were two intranuclear staining patterns in the nuclei of pigmented substantia nigra neurons: a type of inclusion (possible Marinesco bodies) and a diffuse staining. Percentage of nuclear ubiquitin positivity (Ub-positive %) in fire fatalities (2.7-44.7%; mean, 18.5%) was significantly higher than in brain stem injury (n = 9; 0-10.4%; mean, 4.5%) and myocardial infarction (n = 14; 1.5-14.6%; mean, 6.9%), independently of blood carboxyhemoglobin (COHb) levels. Age-dependent increase in Ub-positive % was observed in lower COHb (< 60%) cases. The intranuclear diffuse ubiquitin staining was not observed in cases of high blood cyanide level (> 1.0 microg/ml). These observations showed that intranuclear ubiquitin immunoreactivity of the pigmented substantia nigra neurons in the midbrain was induced by severe stress in fires. |
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Authors:
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L Quan; B L Zhu; S Oritani; K Ishida; M Q Fujita; H Maeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of legal medicine Volume: 114 ISSN: 0937-9827 ISO Abbreviation: Int. J. Legal Med. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-08-17 Completed Date: 2001-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101456 Medline TA: Int J Legal Med Country: Germany |
Other Details:
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Languages: eng Pagination: 310-5 Citation Subset: IM |
Affiliation:
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Department of Legal Medicine, Osaka City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Autopsy Burns / metabolism, pathology* Female Forensic Medicine* Heat-Shock Proteins / analysis Humans Immunohistochemistry Male Middle Aged Neurons / pathology Pigmentation Substantia Nigra / metabolism, pathology* Tissue Distribution Ubiquitin / analysis*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 0/Ubiquitin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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