Document Detail

Intranuclear ubiquitin immunoreactivity in the pigmented neurons of the substantia nigra in fire fatalities.
MedLine Citation:
PMID:  11508795     Owner:  NLM     Status:  MEDLINE    
To evaluate the significance of immunohistochemical staining of ubiquitin (heat shock protein) in the midbrain for medico-legal investigation of death in fires, we examined forensic autopsy cases of fire fatalities (n = 35) in comparison with controls (n = 27; brain stem injury, acute myocardial infarction and carbon monoxide poisoning other than fire fatality). There were two intranuclear staining patterns in the nuclei of pigmented substantia nigra neurons: a type of inclusion (possible Marinesco bodies) and a diffuse staining. Percentage of nuclear ubiquitin positivity (Ub-positive %) in fire fatalities (2.7-44.7%; mean, 18.5%) was significantly higher than in brain stem injury (n = 9; 0-10.4%; mean, 4.5%) and myocardial infarction (n = 14; 1.5-14.6%; mean, 6.9%), independently of blood carboxyhemoglobin (COHb) levels. Age-dependent increase in Ub-positive % was observed in lower COHb (< 60%) cases. The intranuclear diffuse ubiquitin staining was not observed in cases of high blood cyanide level (> 1.0 microg/ml). These observations showed that intranuclear ubiquitin immunoreactivity of the pigmented substantia nigra neurons in the midbrain was induced by severe stress in fires.
L Quan; B L Zhu; S Oritani; K Ishida; M Q Fujita; H Maeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of legal medicine     Volume:  114     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
Department of Legal Medicine, Osaka City University Medical School, Japan.
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MeSH Terms
Aged, 80 and over
Burns / metabolism,  pathology*
Forensic Medicine*
Heat-Shock Proteins / analysis
Middle Aged
Neurons / pathology
Substantia Nigra / metabolism,  pathology*
Tissue Distribution
Ubiquitin / analysis*,  immunology
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Ubiquitin

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