| Intranuclear inclusions of meningioma associated with abnormal cytoskeletal protein expression. | |
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MedLine Citation:
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PMID: 10746966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of meningothelial meningioma with a large number of intranuclear inclusions. Morphologically, these are divided into cytoplasmic inclusions and nuclear vacuoles. The cytoplasmic inclusion has a limiting membrane with cell organelles and filaments. Inclusions of this type are generally eosinophilic, like the cytoplasm. However, there are many inclusions that are more eosinophilic than the cytoplasm or that have a ground-glass appearance. Some of them may contain fine or coarse granules. On the other hand, the nuclear vacuole lacks a limiting membrane and appears empty. In most of the inclusions of this type, there is a faintly basophilic substance in the margin. Generally, the cytoplasmic inclusions are as immunopositive as cytoplasm with vimentin, but some of these cytoplasmic inclusions are more reactive. Under the electron microscope, abnormal aggregation of intermediate filaments is recognized in the cytoplasmic inclusions. It is considered that a strong reaction of cytoplasmic inclusions with vimentin immunostaining is due to abnormal aggregation of intermediate filaments. The present study distinctly demonstrates abnormal localization of intermediate filaments in the cytoplasmic inclusions, and it is suggested that the cytoskeleton participates in the evolution of the cytoplasmic inclusions. |
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Authors:
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T Yoshida; J Hirato; A Sasaki; H Yokoo; Y Nakazato; H Kurachi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Brain tumor pathology Volume: 16 ISSN: 1433-7398 ISO Abbreviation: Brain Tumor Pathol Publication Date: 1999 |
Date Detail:
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Created Date: 2000-06-19 Completed Date: 2000-06-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9716507 Medline TA: Brain Tumor Pathol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 86-91 Citation Subset: IM |
Affiliation:
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First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan. takatomo@news.sb.gunma-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cell Nucleus / chemistry, ultrastructure* Cytoplasm / ultrastructure Cytoskeletal Proteins / analysis*, biosynthesis, genetics Desmin / analysis Gene Expression Regulation, Neoplastic* Humans Immunoenzyme Techniques Inclusion Bodies / chemistry Intracellular Membranes / ultrastructure Keratins / analysis Male Meningeal Neoplasms / genetics, metabolism, pathology* Meningioma / genetics, metabolism, pathology* Microscopy, Electron Mucin-1 / analysis Neoplasm Proteins / analysis*, biosynthesis, genetics Nerve Tissue Proteins / analysis*, biosynthesis, genetics Tumor Markers, Biological / analysis Vacuoles / chemistry, ultrastructure Vimentin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Cytoskeletal Proteins; 0/Desmin; 0/Mucin-1; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Tumor Markers, Biological; 0/Vimentin; 68238-35-7/Keratins |
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