Document Detail

Intranuclear inclusions of meningioma associated with abnormal cytoskeletal protein expression.
MedLine Citation:
PMID:  10746966     Owner:  NLM     Status:  MEDLINE    
We describe a case of meningothelial meningioma with a large number of intranuclear inclusions. Morphologically, these are divided into cytoplasmic inclusions and nuclear vacuoles. The cytoplasmic inclusion has a limiting membrane with cell organelles and filaments. Inclusions of this type are generally eosinophilic, like the cytoplasm. However, there are many inclusions that are more eosinophilic than the cytoplasm or that have a ground-glass appearance. Some of them may contain fine or coarse granules. On the other hand, the nuclear vacuole lacks a limiting membrane and appears empty. In most of the inclusions of this type, there is a faintly basophilic substance in the margin. Generally, the cytoplasmic inclusions are as immunopositive as cytoplasm with vimentin, but some of these cytoplasmic inclusions are more reactive. Under the electron microscope, abnormal aggregation of intermediate filaments is recognized in the cytoplasmic inclusions. It is considered that a strong reaction of cytoplasmic inclusions with vimentin immunostaining is due to abnormal aggregation of intermediate filaments. The present study distinctly demonstrates abnormal localization of intermediate filaments in the cytoplasmic inclusions, and it is suggested that the cytoskeleton participates in the evolution of the cytoplasmic inclusions.
T Yoshida; J Hirato; A Sasaki; H Yokoo; Y Nakazato; H Kurachi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain tumor pathology     Volume:  16     ISSN:  1433-7398     ISO Abbreviation:  Brain Tumor Pathol     Publication Date:  1999  
Date Detail:
Created Date:  2000-06-19     Completed Date:  2000-06-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716507     Medline TA:  Brain Tumor Pathol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan.
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MeSH Terms
Cell Nucleus / chemistry,  ultrastructure*
Cytoplasm / ultrastructure
Cytoskeletal Proteins / analysis*,  biosynthesis,  genetics
Desmin / analysis
Gene Expression Regulation, Neoplastic*
Immunoenzyme Techniques
Inclusion Bodies / chemistry
Intracellular Membranes / ultrastructure
Keratins / analysis
Meningeal Neoplasms / genetics,  metabolism,  pathology*
Meningioma / genetics,  metabolism,  pathology*
Microscopy, Electron
Mucin-1 / analysis
Neoplasm Proteins / analysis*,  biosynthesis,  genetics
Nerve Tissue Proteins / analysis*,  biosynthesis,  genetics
Tumor Markers, Biological / analysis
Vacuoles / chemistry,  ultrastructure
Vimentin / analysis
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Desmin; 0/Mucin-1; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Tumor Markers, Biological; 0/Vimentin; 68238-35-7/Keratins

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