Document Detail


Intranodular signal intensity analysis of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI.
MedLine Citation:
PMID:  22884705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To analyze intranodular signal intensity pattern of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI.
METHODS: A total of 73 nodules showing hypervascular foci in hypovascular high-risk borderline lesions identified by angiography-assisted CT were included in this study. The intranodular signal intensities of both the hypervascular foci and the hypovascular high-risk borderline lesions were evaluated on hepatobiliary-phase EOB-enhanced MRI obtained 20 min after intravenous injection of contrast media.
RESULTS: Among 59 hypervascular foci within hypointense hypovascular high-risk borderline lesions, 6 showed more hypointensity, 32 isointensity, and 21 hyperintensity compared to the surrounding hypointense, hypovascular portion of the nodules. Among 14 hypervascular foci within isointense hypovascular high-risk borderline lesions, 5 showed isointensity, and 9 hypointensity compared to the surrounding isointense hypovascular high-risk borderline lesions. No hypervascular foci showed hyperintensity compared to the surrounding isointense hypovascular high-risk borderline lesions.
CONCLUSIONS: In most of the hypovascular high-risk borderline lesions containing hypervascular foci within the nodule, the signal intensity was decreased in hypervascular foci as compared with hypovascular high-risk borderline lesions and the surrounding background liver parenchyma. This supports the concept of signal intensity decrease during the dedifferentiation process in multistep hepatocarcinogenesis. However, around 30% of the nodules did not follow this rule, and hypervascular foci showed hyperintensity relative to the hypovascular high-risk borderline lesions.
Authors:
Satoshi Kobayashi; Osamu Matsui; Toshifumi Gabata; Wataru Koda; Tetsuya Minami; Yasuji Ryu; Kazuto Kozaka; Azusa Kitao
Related Documents :
20396655 - Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage.
9715495 - Cavernous hemangiomas of the orbital apex with intracranial extension.
18581605 - Atypical angioma serpiginosum.
11061695 - Angiomatous skeletal lesions.
8935225 - Ct and mri findings of eclampsia and their correlation with neurologic symptoms.
2153625 - The consequences of unsuspected secondary ovarian neoplasia: a clinical presentation of...
Publication Detail:
Type:  Journal Article     Date:  2012-08-10
Journal Detail:
Title:  European journal of radiology     Volume:  81     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-29     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  3839-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Dept of Radiology, Kanazawa University School of Medicine, 13-1, Takara Machi, Kanazawa 920-8641, Japan. satoshik@staff.kanazawa-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Algorithms*
Carcinoma, Hepatocellular / complications,  pathology*
Contrast Media
Early Diagnosis
Female
Gadolinium DTPA / diagnostic use*
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Liver Neoplasms / complications,  pathology*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Neovascularization, Pathologic / complications,  pathology*
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA
Comments/Corrections
Comment In:
Rofo. 2013 Jun;185(6):525   [PMID:  23740706 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biologically and chemically mediated adsorption and precipitation of phosphorus from wastewater.
Next Document:  Flip angle modulations in late phase Gd-EOB-DTPA MRI improve the identification of the biliary syste...