Document Detail

Intranodular signal intensity analysis of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI.
MedLine Citation:
PMID:  22884705     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To analyze intranodular signal intensity pattern of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI.
METHODS: A total of 73 nodules showing hypervascular foci in hypovascular high-risk borderline lesions identified by angiography-assisted CT were included in this study. The intranodular signal intensities of both the hypervascular foci and the hypovascular high-risk borderline lesions were evaluated on hepatobiliary-phase EOB-enhanced MRI obtained 20 min after intravenous injection of contrast media.
RESULTS: Among 59 hypervascular foci within hypointense hypovascular high-risk borderline lesions, 6 showed more hypointensity, 32 isointensity, and 21 hyperintensity compared to the surrounding hypointense, hypovascular portion of the nodules. Among 14 hypervascular foci within isointense hypovascular high-risk borderline lesions, 5 showed isointensity, and 9 hypointensity compared to the surrounding isointense hypovascular high-risk borderline lesions. No hypervascular foci showed hyperintensity compared to the surrounding isointense hypovascular high-risk borderline lesions.
CONCLUSIONS: In most of the hypovascular high-risk borderline lesions containing hypervascular foci within the nodule, the signal intensity was decreased in hypervascular foci as compared with hypovascular high-risk borderline lesions and the surrounding background liver parenchyma. This supports the concept of signal intensity decrease during the dedifferentiation process in multistep hepatocarcinogenesis. However, around 30% of the nodules did not follow this rule, and hypervascular foci showed hyperintensity relative to the hypovascular high-risk borderline lesions.
Satoshi Kobayashi; Osamu Matsui; Toshifumi Gabata; Wataru Koda; Tetsuya Minami; Yasuji Ryu; Kazuto Kozaka; Azusa Kitao
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Publication Detail:
Type:  Journal Article     Date:  2012-08-10
Journal Detail:
Title:  European journal of radiology     Volume:  81     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-29     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  3839-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Dept of Radiology, Kanazawa University School of Medicine, 13-1, Takara Machi, Kanazawa 920-8641, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Hepatocellular / complications,  pathology*
Contrast Media
Early Diagnosis
Gadolinium DTPA / diagnostic use*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Liver Neoplasms / complications,  pathology*
Magnetic Resonance Imaging / methods*
Middle Aged
Neovascularization, Pathologic / complications,  pathology*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA
Comment In:
Rofo. 2013 Jun;185(6):525   [PMID:  23740706 ]

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