Document Detail

Intraneural ganglia: a clinical problem deserving a mechanistic explanation and model.
MedLine Citation:
PMID:  19435441     Owner:  NLM     Status:  MEDLINE    
Intraneural ganglion cysts have been considered a curiosity for 2 centuries. Based on a unifying articular (synovial) theory, recent evidence has provided a logical explanation for their formation and propagation. The fundamental principle is that of a joint origin and a capsular defect through which synovial fluid escapes following the articular branch, typically into the parent nerve. A stereotypical, reproducible appearance has been characterized that suggests a shared pathogenesis. In the present report the authors will provide a mechanistic explanation that can then be mathematically tested using a preliminary model created by finite element analysis.
Shreehari Elangovan; Gregory M Odegard; Duane A Morrow; Huan Wang; Marie-Noëlle Hébert-Blouin; Robert J Spinner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgical focus     Volume:  26     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E11     Citation Subset:  IM    
Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan, USA.
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MeSH Terms
Computer Simulation
Finite Element Analysis
Ganglion Cysts / etiology,  pathology,  physiopathology*
Joints / innervation,  pathology,  physiopathology*
Peripheral Nerves / pathology,  physiopathology*
Peripheral Nervous System Diseases / etiology,  pathology,  physiopathology*
Pressure / adverse effects
Synovial Fluid / physiology
Synovial Membrane / innervation,  pathology,  physiopathology*

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