Document Detail


Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone.
MedLine Citation:
PMID:  18804503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effect of hormonal environment on intranasal and subcutaneous routes of immunization in a genital herpes infection model. Ovariectomized mice were treated with estradiol (E(2)), progesterone (P(4)) or placebo hormone pellets and immunized intranasally (i.n.) or subcutaneously (s.c.) with attenuated HSV-2. Immunized mice were subsequently challenged, intravaginally, with wild-type HSV-2. Mice immunized under the influence of E(2) showed higher survival rates, reduced pathology and significantly lower viral shedding compared with those immunized under the influence of P(4) or placebo, by both i.n. and s.c. routes. Vaginal and serum anti-HSV-2 IgG, but not IgA, levels correlated with decreased pathology in E(2)-treated, i.n. immunized mice. We conclude that immunization under the influence of E(2) afforded better protection compared to placebo and P(4), by both routes of immunization. Female sex hormones can influence immune responses and outcome of viral challenge in the genital tract following systemic immunization.
Authors:
Sudha Bhavanam; Denis P Snider; Charu Kaushic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-18
Journal Detail:
Title:  Vaccine     Volume:  26     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  6165-72     Citation Subset:  IM    
Affiliation:
Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Animals
Enzyme-Linked Immunosorbent Assay
Estradiol / pharmacology*
Female
Herpes Genitalis / immunology*,  pathology,  prevention & control*
Herpesvirus 2, Human / immunology*
Immunoglobulin A / biosynthesis,  immunology
Immunoglobulin G / biosynthesis,  immunology
Injections, Subcutaneous
Mice
Mice, Inbred C57BL
Ovariectomy
Progesterone / pharmacology*
Vagina / immunology,  pathology
Virus Replication / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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