Document Detail

Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography.
MedLine Citation:
PMID:  20180109     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Voiding cystourethrogram (VCUG) is a common procedure at pediatric tertiary care centres that can be painful as it involves a urinary catheter. Currently there are no widely utilized protocols for non-topical medications to decrease pain that children feel during catheterization. OBJECTIVE: To determine if intranasal (IN) fentanyl is effective at decreasing pain that children feel during catheterization of VCUG when compared with sterile water. MATERIALS AND METHODS: We performed a double-blind randomized controlled trial, using IN fentanyl (2 microg/kg) compared to placebo (sterile water,) in children 4-8 years of age scheduled for elective VCUG in one urban pediatric tertiary center. RESULTS: Using the Face Pain Score-Revised, children receiving IN fentanyl scored 2.58 (1.93-3.25 95% CI) while those receiving sterile water scored 2.86 (2.20-3.51 95% CI) showing no statistically significant difference. There were no adverse events. CONCLUSIONS: Although we were unable to show a statistically significant difference between our study and control groups, we believe that this may be due to technique (positioning, delivery device) and timing of administration of IN fentanyl as well as multi-factorial causes of distress during VCUG. Future studies investigating alternative delivery techniques of IN fentanyl for analgesia during VCUG may yield more promising results.
Seen Chung; Ruth Lim; Ran D Goldman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-02-24
Journal Detail:
Title:  Pediatric radiology     Volume:  40     ISSN:  1432-1998     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1236-40     Citation Subset:  IM    
Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
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MeSH Terms
Administration, Intranasal
Analgesics, Opioid / administration & dosage
Child, Preschool
Double-Blind Method
Fentanyl / administration & dosage*
Pain / etiology*,  prevention & control*
Pain Measurement / drug effects
Placebo Effect
Treatment Outcome
Urinary Catheterization / adverse effects*
Urography / adverse effects*
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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