| Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography. | |
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MedLine Citation:
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PMID: 20180109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Voiding cystourethrogram (VCUG) is a common procedure at pediatric tertiary care centres that can be painful as it involves a urinary catheter. Currently there are no widely utilized protocols for non-topical medications to decrease pain that children feel during catheterization. OBJECTIVE: To determine if intranasal (IN) fentanyl is effective at decreasing pain that children feel during catheterization of VCUG when compared with sterile water. MATERIALS AND METHODS: We performed a double-blind randomized controlled trial, using IN fentanyl (2 microg/kg) compared to placebo (sterile water,) in children 4-8 years of age scheduled for elective VCUG in one urban pediatric tertiary center. RESULTS: Using the Face Pain Score-Revised, children receiving IN fentanyl scored 2.58 (1.93-3.25 95% CI) while those receiving sterile water scored 2.86 (2.20-3.51 95% CI) showing no statistically significant difference. There were no adverse events. CONCLUSIONS: Although we were unable to show a statistically significant difference between our study and control groups, we believe that this may be due to technique (positioning, delivery device) and timing of administration of IN fentanyl as well as multi-factorial causes of distress during VCUG. Future studies investigating alternative delivery techniques of IN fentanyl for analgesia during VCUG may yield more promising results. |
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Authors:
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Seen Chung; Ruth Lim; Ran D Goldman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-02-24 |
Journal Detail:
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Title: Pediatric radiology Volume: 40 ISSN: 1432-1998 ISO Abbreviation: Pediatr Radiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365332 Medline TA: Pediatr Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 1236-40 Citation Subset: IM |
Affiliation:
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Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Analgesics, Opioid / administration & dosage Child Child, Preschool Double-Blind Method Female Fentanyl / administration & dosage* Humans Male Pain / etiology*, prevention & control* Pain Measurement / drug effects Placebo Effect Treatment Outcome Urinary Catheterization / adverse effects* Urination Urography / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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