| Intranasal delivery of calcitonin gene-related peptide reduces cerebral vasospasm in rats. | |
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MedLine Citation:
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PMID: 20515821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral vasospasm is the primary cause of sequelae and poor clinical conditions of subarachnoid hemorrhage (SAH); therefore, it is imperative to relieve vasospasm and improve cerebral blood supply. Calcitonin gene-related peptide (CGRP) is a potent vasodilator that is normally released by trigeminal sensory fibers but depleted following SAH. We propose that intranasal application may be an effective way to deliver CGRP to the brain and ameliorate vasospasm after SAH. In this study, we intranasally applied CGRP to rats and induced SAH by double-injection of autologous blood into the cisterna magna. Compared to intravenous injection, intranasal delivery led to a 10-fold higher level of CGRP in the brain. Intranasal CGRP significantly ameliorated vasospasm, improved cerebral blood flow, and reduced cortical and endothelial cell death. Moreover, CGRP increased the levels of vascular endothelial growth factor and stimulated angiogenesis. Altogether, our data demonstrate that intranasal CGRP delivery is a promising method for moderating vasospasm and reducing the associated ischemic brain injury after SAH in rats, and suggest that it may be a potential approach in clinic. |
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Authors:
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Bao-liang Sun; Fa-ping Shen; Qing-jian Wu; Shu-mei Chi; Ming-feng Yang; Hui Yuan; Fang-min Xie; Yan-bo Zhang; Jun Chen; Feng Zhang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 2 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 1502-13 Citation Subset: IM |
Affiliation:
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Department of Neurology, Key Laboratory of Cerebral Microcirculation, Universities of Shandong, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China. blsun88@163.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Animals Base Sequence Blotting, Western Calcitonin Gene-Related Peptide / administration & dosage*, therapeutic use DNA Primers Disease Models, Animal Immunohistochemistry Male RNA, Messenger / genetics Rats Rats, Wistar Transcription, Genetic Vascular Endothelial Growth Factor A / genetics, metabolism Vasospasm, Intracranial / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/RNA, Messenger; 0/Vascular Endothelial Growth Factor A; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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