| Intranasal corticosteroid use is associated with lower rates of bacterial recovery in chronic rhinosinusitis. | |
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MedLine Citation:
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PMID: 17418259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether use of a topical intranasal corticosteroid (INCS) preoperatively had an effect on the bacterial recovery rate and flora recovered at endoscopic sinus surgery (ESS). STUDY DESIGN AND SETTING: A prospective, multicenter, observational study from academic-based rhinology practices. Consecutive, unselected patients undergoing ESS had protected sinus cultures done at the time of ESS. RESULTS: 157 patients were assessed. Overall growth rate was 45.5%. INCS users had a positive culture rate of 35.4% vs 61.7% in nonusers (P = 0.0001). This effect was most pronounced in the subgroup undergoing revision surgeries (bacterial recovery rate INCS: 40.0%, no INCS: 82.6%, P = 0.001) and most marked for S. aureus (INCS: 12.5%, no INCS: 40.0%, P = 0.04) and CNS (INCS: 12.5%, no INCS: 30.4%, P = 0.05). While the rate of nasal polyposis was higher in both revision and the INCS-treated groups, rate of bacterial recovery was not influenced by a diagnosis of nasal polyposis. CONCLUSION: INCS use preoperatively is associated with a lesser rate of bacterial recovery at the time of ESS, especially in individuals with previous ESS. SIGNIFICANCE: The results suggest a possible role of INCS in the management of post-ESS disease. |
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Authors:
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Martin Desrosiers; Abdolmohsen Hussain; Saul Frenkiel; Shaun Kilty; Joseph Marsan; Ian Witterick; Erin Wright |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 136 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 605-9 Citation Subset: IM |
Affiliation:
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Canadian Society of Otololaryngology-Head and Neck Surgery Rhinology group and Department of Otolaryngology, Hotel-Dieu de Montreal, Montreal, Quebec, Canada. desrosiers_martin@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Chronic Disease Glucocorticoids / administration & dosage* Humans Prednisone / administration & dosage* Prospective Studies Rhinitis / complications, drug therapy*, microbiology*, surgery Sinusitis / complications, drug therapy*, microbiology*, surgery Staphylococcus / isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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