| Intranasal buserelin versus surgery in the treatment of uterine leiomyomata: long-term follow-up. | |
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MedLine Citation:
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PMID: 1899079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-two women with symptomatic uterine myomas, candidates for myomectomy or hysterectomy, were randomized to 6 months' treatment with buserelin 1200 micrograms/day intranasally (n = 22) or immediate surgery (n = 20). After buserelin treatment or operation the patients were followed for at least 12 months. Buserelin was well tolerated, the uterine volume fell from 465 +/- 168 to 273 +/- 88 cm3, and hemoglobin values normalized in all anemic patients. Rapid myoma regrowth was observed in all patients in the buserelin group after treatment withdrawal. Pregnancy occurred during follow-up in one of five buserelin-treated myomectomy candidates. Menorrhagia recurred in eight of 15 buserelin-treated hysterectomy candidates, and a hysterectomy was required but no transfusion was needed. Two women entered natural menopause and were considered cured. In the surgery group all operations were uneventful: three women conceived after myomectomy, whereas four of the patients that underwent hysterectomy required transfusions. Thus buserelin treatment appears to be indicated for infertile patients when surgery is contra-indicated or could cause adhesions, and for hysterectomy candidates in perimenopausal age and/or with secondary anemia. |
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Authors:
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L Fedele; S Bianchi; A Baglioni; L Arcaini; M Marchini; L Bocciolone |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 38 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-27 Completed Date: 1991-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: IM |
Affiliation:
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First Department of Obstetrics and Gynecology, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Adult Analysis of Variance Buserelin / administration & dosage*, pharmacology Female Follow-Up Studies Gonadotropin-Releasing Hormone / physiology Humans Hysterectomy Leiomyoma / drug therapy*, surgery Middle Aged Uterine Neoplasms / drug therapy*, surgery |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; 57982-77-1/Buserelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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