Document Detail


Intranasal benzo[a]pyrene alters circadian blood pressure patterns and causes lung inflammation in rats.
MedLine Citation:
PMID:  20848083     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are environmental contaminants formed during organic material combustion (e.g. burning fossil fuels and cigarette smoke). BaP toxicity is mediated, in part, by activation of the aryl hydrocarbon receptor and formation of reactive metabolites, both of which lead to increased oxidative stress. Since air pollution and cigarette smoking are known to increase cardiovascular disease in humans, the objective of this study was to determine the effects of 7-day intranasal BaP exposure on circadian blood pressure patterns, arterial stiffness, and possible sources of oxidative stress in radiotelemetry-implanted rats. Arterial pulse wave dP/dt was used an indicator of arterial stiffness and was compared to both functional (nitric oxide production and bioactivity, endothelin-1 levels) and structural (wall thickness) features of the arterial wall. In addition, histology of lung, heart, and liver were examined as well as pulmonary and hepatic cytochrome P450 1A1 (CYP1A1) activity. BaP exposure altered the circadian pattern of blood pressure, with a reduction in the normal dipping pattern during sleep. This was associated with increased neutrophil recruitment in the lungs of BaP-exposed rats. In contrast, BaP had no effect on cardiovascular tissue histology, arterial stiffness, oxidative stress or lung and liver CYP1A1 activity. Thus, the current study does not support the hypothesis that BaP reactive metabolites increase oxidative stress leading to reduced vascular NO bioactivity and increased blood pressure. Instead, the current study suggests that inflammation, detected only in the lung, is associated with altered circadian rhythm of blood pressure.
Authors:
Nicole J Gentner; Lynn P Weber
Related Documents :
7533553 - The mechanism underlying stimulation of gastric hco3- secretion by the nitric oxide syn...
9256283 - The control of microvascular permeability and blood pressure by neutral endopeptidase.
2994933 - Modulation of right and left ventricular wall thicknesses in experimental hypertension.
Publication Detail:
Type:  Journal Article     Date:  2010-09-17
Journal Detail:
Title:  Archives of toxicology     Volume:  85     ISSN:  1432-0738     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  337-46     Citation Subset:  IM    
Affiliation:
Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of in vitro antagonism and of in vivo immune modulation and protection against pathogenic...
Next Document:  Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactiv...