| Intranasal administration of insulin lowers amyloid-beta levels in rat model of diabetes. | |
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MedLine Citation:
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PMID: 22279939 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal accumulation of amyloid beta (A beta) peptide in brain regions subserving memory and other cognitive functions. Hyperglycemia and perturbed insulin signaling have been proposed as pathogenic factors contributing to AD. The aim of the present study is to validate the use of streptozotocin (STZ) injected rats as an experimental model of AD. Using this model, the effect of intranasal administration of insulin on reduction of A beta levels was measured. The current findings strengthen the case for insulin as therapy for AD afflicted individuals with or without diabetes. |
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Authors:
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Sarada Subramanian; Mathew John |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 50 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560 029, India. sarada@nimhans.kar.nic.in |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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