Document Detail


Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability.
MedLine Citation:
PMID:  12626469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vastus lateralis intramyocellular lipid (IMCL) content was assessed by (1)H-magnetic resonance spectroscopy before and after prolonged time trial cycling bouts of approximately 3-h duration. Six highly trained male cyclists completed a double-blind, randomized, crossover design of two experimental trials after a strenuous exercise bout and 48 h of high (HC) (9.32 +/- 0.08 g. kg(-1). day(-1)) and low (LC) (0.59 +/- 0.21 g. kg(-1). day(-1)) dietary carbohydrate. Resting IMCL content was significantly higher after LC vs. HC (P < 0.01) and was reduced during exercise by 64 and 57%, respectively. IMCL was not different between conditions after exercise (P > 0.05). The approximately twofold increase in IMCL degradation in LC compared with HC suggests that higher rates of whole body lipid metabolism in LC were in part attributable to a greater IMCL utilization. Four subjects experienced reductions of IMCL in excess of 70% during exercise. To our knowledge, this is the first study to report near depletion of IMCL during prolonged cycling, indicating that IMCL, presumably the triacylglycerol component, may be exhausted by prolonged strenuous exercise.
Authors:
N A Johnson; S R Stannard; K Mehalski; M I Trenell; T Sachinwalla; C H Thompson; M W Thompson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial     Date:  2002-11-27
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-10-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1365-72     Citation Subset:  IM    
Affiliation:
School of Exercise and Sport Science, The University of Sydney, Lidcombe 1825, New South Wales, Australia. hjohnson@ihug.com.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling / physiology*
Biological Availability
Body Fluids / metabolism
Body Weight
Cross-Over Studies
Dietary Carbohydrates / pharmacokinetics*
Double-Blind Method
Fatty Acids, Nonesterified / blood
Gases
Glycerol / blood
Humans
Magnetic Resonance Spectroscopy
Male
Muscle, Skeletal / metabolism*
Respiration
Thigh
Time Factors
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Fatty Acids, Nonesterified; 0/Gases; 0/Triglycerides; 56-81-5/Glycerol
Comments/Corrections
Comment In:
J Sports Sci. 2005 May;23(5):549-57   [PMID:  16195003 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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