Document Detail

Intramyocellular lipids: effect of age, obesity, and exercise.
MedLine Citation:
PMID:  20048484     Owner:  NLM     Status:  MEDLINE    
Obese individuals with metabolic syndrome are predicted to have a 5 times greater risk of developing type 2 diabetes and a 3 times greater risk of myocardial infarction than those without metabolic syndrome. Many obese patients with metabolic risk factors have an accumulation of triglycerides within the skeletal muscle fibers, ie, intramyocellular lipids (IMCL). Individuals with metabolic syndrome have a greater risk of developing IMCL depots, and these stores are related to increased cardiovascular risk and type 2 diabetes. A few studies have shown, moreover, that aging seems to result in an increase in IMCL stores, although little is known about how exercise influences these stores. In healthy young individuals, IMCL depots have been shown to decrease in response to acute exercise, but very little is known about the effects of exercise training on IMCL depots in obese individuals. Understanding how IMCL depots can be altered with exercise (both resistance and aerobic exercise) in older and obese individuals seems to be critical in preventing disease.
Ruth M Franklin; Jill A Kanaley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Physician and sportsmedicine     Volume:  37     ISSN:  0091-3847     ISO Abbreviation:  Phys Sportsmed     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0427461     Medline TA:  Phys Sportsmed     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Department of Exercise Science, Syracuse University, Syracuse, NY 13244, USA.
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MeSH Terms
Age Factors
Aging / physiology*
Diabetes Mellitus, Type 2 / metabolism
Exercise / physiology*
Lipid Metabolism / physiology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Metabolic Syndrome X / metabolism
Muscle Fibers, Skeletal / metabolism*
Muscle, Skeletal / metabolism,  physiology
Obesity / metabolism*
Overweight / metabolism

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