| Intramyocellular lipids: effect of age, obesity, and exercise. | |
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MedLine Citation:
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PMID: 20048484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obese individuals with metabolic syndrome are predicted to have a 5 times greater risk of developing type 2 diabetes and a 3 times greater risk of myocardial infarction than those without metabolic syndrome. Many obese patients with metabolic risk factors have an accumulation of triglycerides within the skeletal muscle fibers, ie, intramyocellular lipids (IMCL). Individuals with metabolic syndrome have a greater risk of developing IMCL depots, and these stores are related to increased cardiovascular risk and type 2 diabetes. A few studies have shown, moreover, that aging seems to result in an increase in IMCL stores, although little is known about how exercise influences these stores. In healthy young individuals, IMCL depots have been shown to decrease in response to acute exercise, but very little is known about the effects of exercise training on IMCL depots in obese individuals. Understanding how IMCL depots can be altered with exercise (both resistance and aerobic exercise) in older and obese individuals seems to be critical in preventing disease. |
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Authors:
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Ruth M Franklin; Jill A Kanaley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Physician and sportsmedicine Volume: 37 ISSN: 0091-3847 ISO Abbreviation: Phys Sportsmed Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2010-01-05 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0427461 Medline TA: Phys Sportsmed Country: United States |
Other Details:
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Languages: eng Pagination: 20-6 Citation Subset: IM |
Affiliation:
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Department of Exercise Science, Syracuse University, Syracuse, NY 13244, USA. rmfrankl@syr.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / physiology* Diabetes Mellitus, Type 2 / metabolism Exercise / physiology* Humans Lipid Metabolism / physiology* Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Metabolic Syndrome X / metabolism Muscle Fibers, Skeletal / metabolism* Muscle, Skeletal / metabolism, physiology Obesity / metabolism* Overweight / metabolism |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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