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Intramyocellular lipid variations in active older men: relationship with aerobic fitness.
MedLine Citation:
PMID:  23217190     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Intramyocellular lipids (IMCL) variations in older men are poorly explored. In young adults, IMCL can be influenced both by diet and exercise interventions; this flexibility is related to aerobic fitness. We evaluated in active older adults, the influence of maximal aerobic capacity on short-term diet and exercise-induced variations in IMCL stores. METHODS: IMCL were measured by (1) H magnetic resonance spectroscopy ((1) H-MRS) after a 3-day fat depletion-replenishment diet (IMCL(FDR) ) and immediately after a 2-hour exercise at 50% VO(2) max (IMCL(FDR_EX) ). To further explore diet influence, the protocol was repeated after a high fat diet (HF), with both pre and post exercise measurements (IMCL(HF) and IMCL(HF_EX) ). RESULTS: In active older men (69.8±5.2 years), IMCL(FDR) were lowered by exercise (IMCL(FDR) = 3.45±1.52 vs. IMCL(FDR_EX) =2.74±1.15 mmol kg(-1) wet weight, p<0.05), and exercise-induced variations were correlated to the initial store (p<0.05, r=-0.72). IMCL(FDR) were linked with aerobic fitness (p<0.05, r=0.76), when adjusted by fat mass. IMCL(HF) were lower than IMCL(FDR) (p<0.05), decreased after exercise (p<0.05), and varied also as a function of initial store (p<0.05, r=-0.89), but without link with aerobic fitness. Finally, diet-induced IMCL store variations was positively linked to aerobic fitness (p<0.05, r=0.89). CONCLUSION: Variations of the IMCL stores in physically active older adults appears related to aerobic fitness, with similarly fast adaptation to short-term interventions combining diet and exercise as young active adults. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Authors:
David Rouffet; Clément Villars; Rachida Fissoune; Dominique Sappey-Marinier; Martine Laville; Danielle Ibarrola; Monique Sothier; Marie-France Monnet; Michel Ovize; Marc Bonnefoy; Chris Boesch; Emmanuelle Canet-Soulas
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Affiliation:
University Lyon 1, CarMeN, U1060 INSERM, INSA Lyon, INRA; ISEAL, Victoria University, Melbourne, Australia.
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