| Intramyocardial fibroblast myocyte communication. | |
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MedLine Citation:
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PMID: 20056945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in extracellular matrix homeostasis, and direct cell-cell interactions. It is possible that they are a contributor to the inability of adult myocytes to proliferate and may influence cardiac progenitor biology. Furthering our understanding of how cardiac fibroblasts and myocytes interact may provide an avenue to novel treatments for heart failure prevention. This review discusses the most recent concepts in cardiac fibroblast-myocyte communication and areas of potential future research. |
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Authors:
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Rahul Kakkar; Richard T Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Circulation research Volume: 106 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-08 Completed Date: 2010-01-22 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 47-57 Citation Subset: IM |
Affiliation:
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Cardiology Division, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Extracellular Matrix / metabolism, pathology Fibroblasts / metabolism*, pathology Heart Failure / metabolism*, pathology* Humans Myocytes, Cardiac / metabolism*, pathology Paracrine Communication* |
| Grant Support | |
ID/Acronym/Agency:
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AG032977/AG/NIA NIH HHS; HL092930/HL/NHLBI NIH HHS; R01 HL092930-02/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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