Document Detail


Intramyocardial fibroblast myocyte communication.
MedLine Citation:
PMID:  20056945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in extracellular matrix homeostasis, and direct cell-cell interactions. It is possible that they are a contributor to the inability of adult myocytes to proliferate and may influence cardiac progenitor biology. Furthering our understanding of how cardiac fibroblasts and myocytes interact may provide an avenue to novel treatments for heart failure prevention. This review discusses the most recent concepts in cardiac fibroblast-myocyte communication and areas of potential future research.
Authors:
Rahul Kakkar; Richard T Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Circulation research     Volume:  106     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-01-22     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Extracellular Matrix / metabolism,  pathology
Fibroblasts / metabolism*,  pathology
Heart Failure / metabolism*,  pathology*
Humans
Myocytes, Cardiac / metabolism*,  pathology
Paracrine Communication*
Grant Support
ID/Acronym/Agency:
AG032977/AG/NIA NIH HHS; HL092930/HL/NHLBI NIH HHS; R01 HL092930/HL/NHLBI NIH HHS; R01 HL092930-02/HL/NHLBI NIH HHS
Comments/Corrections

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