| Intramyocardial Implantation of bone marrow-derived stem cells enhances perfusion in chronic myocardial infarction: dependency on initial perfusion depth and follow-up assessed by gated pinhole SPECT. | |
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MedLine Citation:
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PMID: 17332618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell therapy-induced changes in the perfusion of areas of myocardial infarction (MI) remain unclear. This study investigated whether an original pinhole SPECT technique could be applied to a rat MI model to analyze local improvement in myocardial perfusion relating to engraftment sites of bone marrow-derived stem cells (BMSCs). METHODS: Four-month-old MI rats were either untreated (n = 8) or treated (n = 10) by intramyocardial injection of (111)In-labeled BMSCs. Early distribution of (111)In-BMSCs within the MI target was evidenced by dual (111)In/(99m)Tc pinhole SPECT 48 h later. Myocardial perfusion was serially monitored by (99m)Tc-sestamibi pinhole gated SPECT up to 3 mo after transplantation. RESULTS: Forty-eight hours after transplantation, (111)In-BMSCs were observed in all treated rats and in 18 of their 32 underperfused MI segments (<70% sestamibi uptake before transplantation). During the subsequent 3-mo follow-up, the perfusion of MI segments worsened in untreated rats (absolute change in sestamibi uptake, -3% +/- 3%; P < 0.05) but improved in treated rats (+4% +/- 7%; P < 0.05). This perfusion improvement was unrelated to the initial detection of (111)In-BMSCs (+2% +/- 6% in segments with (111)In-BMSCs vs. +5% +/- 7% in those without; not statistically significant) but was strongly associated with less severe perfusion defects before transplantation (+6% +/- 6% in segments with 60%-70% sestamibi uptake [n = 19] vs. -1% +/- 6% in those with <60% uptake [n = 13]; P = 0.003). CONCLUSION: When BMSCs are injected within chronic MI, perfusion enhancement predominates in the MI areas showing a high enough residual perfusion before treatment but not in those of the initial cell engraftment, giving evidence of dependency on the perfusion and metabolic environment at implantation sites. |
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Authors:
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Nguyen Tran; Philippe R Franken; Fatiha Maskali; Joseph Nloga; Pablo Maureira; Sylvain Poussier; Frederique Groubatch; Chris Vanhove; Jean-Pierre Villemot; Pierre-Yves Marie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 48 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-02 Completed Date: 2007-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Affiliation:
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School of Surgery, Faculty of Medicine-UHP, Nancy, France. Nguyen.Tran@medecine.uhp-nancy.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells / cytology* Chronic Disease Coronary Circulation* Follow-Up Studies Heart / radionuclide imaging* Indium Radioisotopes / diagnostic use Male Myocardial Infarction / physiopathology, radionuclide imaging, surgery* Rats Rats, Wistar Stem Cell Transplantation* Tomography, Emission-Computed, Single-Photon* Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Indium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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