Document Detail

Intramuscular vs intravaginal natural progesterone in patients undergoing in vitro fertilization-embryo transfer cycles. A retrospective observational, case-control study.
MedLine Citation:
PMID:  20329568     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effectiveness of intramuscular (IM) and intravaginal (IV) progesterone for luteal phase support, in patients undergoing in vitro fertilization-embryo transfer cycles (IVF-ET).
DESIGN: retrospective, observational, case-control study
SETTING: Centro Natalità, San Raffaele Hospital, Milan, Italy, from July 2007 to June 2009.
PATIENT(S): 172 A-GnRH down-regulated IVF-ET cycles in patients with age < 40 years.
INTERVENTION(S): Luteal phase support with IM progesterone (50 mg daily) or IV progesterone (90 mg daily).
MAIN OUTCOME MEASURE(S): Biochemical pregnancy, clinical pregnancy, miscarriage, ongoing pregnancy rates and patient's acceptability.
RESULTS: IM progesterone conferred more benefit compared with IV progesterone in terms of ongoing pregnancy rate (24.4% vs 12.7%; P < 0.05).
CONCLUSIONS: In standard IVF cycles, our data showed that IM progesterone appears to be more effective at providing luteal support, thus rendering with IV progesterone.
E Papaleo; L Quaranta; M Molgora
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  14     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-04-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  103-6     Citation Subset:  IM    
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MeSH Terms
Administration, Intravaginal
Case-Control Studies
Embryo Transfer*
Fertilization in Vitro*
Injections, Intramuscular
Progesterone / administration & dosage*
Retrospective Studies
Reg. No./Substance:

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