Document Detail

Intramuscular route of progesterone administration increases pregnancy rates during non-downregulated frozen embryo transfer cycles.
MedLine Citation:
PMID:  17721816     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The optimal route of progesterone (P4) administration in embryo transfer (FET) cycles remains to be determined. The objective of this study is to compare the pregnancy outcomes between intramuscular (IM) and vaginal progesterone (PV) administration for endometrial preparation in non-donor FET cycles.
STUDY DESIGN: A retrospective clinical study in a private practice infertility setting.
RESULTS: No significant differences in patient demographics and embryo characteristics were noted between the two groups. The clinical pregnancy rate as well as the live birth rate were significantly higher in the IM arm compared to the PV arm (38.2% vs 28%, 34.5 % vs 22.8%, respectively).
CONCLUSION: Although both routes of progesterone administration had similar rates of initial positive pregnancy tests, the IM route had a significantly higher live birth rate. The exact reason for this difference remains to be determined.
Ghassan Haddad; Docile A Saguan; Rose Maxwell; Michael A Thomas
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Publication Detail:
Type:  Journal Article     Date:  2007-08-25
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  24     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-01-14     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM    
University of Cincinnati Medical Center, Cincinnati, OH, USA.
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MeSH Terms
Administration, Intravaginal
Embryo Transfer / methods*
Injections, Intramuscular
Live Birth*
Pregnancy Rate*
Progesterone / administration & dosage*,  blood
Retrospective Studies
Reg. No./Substance:

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