| Intramuscular prochlorperazine versus metoclopramide as single-agent therapy for the treatment of acute migraine headache. | |
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MedLine Citation:
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PMID: 8639197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the efficacy of intramuscular prochlorperazine and metoclopramide in the short-term treatment of migraine headache in the emergency department 86 eligible adult patients with moderate to severe migraine headache were evaluated prospectively at a university-affiliated community hospital. After randomization, each subject received a 2-mL intramuscular injection of sterile saline, prochlorperazine (10 mg), or metoclopramide (10 mg). No other analgesics were administered during the 60-minute study period; patient assessment of relief was followed using visual analog scales. Reduction in median headache scores was significantly better among those treated with prochlorperazine (67%) compared to metoclopramide (34%) or placebo (16%). Similarly, symptoms of nausea and vomiting were significantly relieved in the prochlorperazine group (chi 2 = 17.1, P < .001). However, rescue analgesic therapy was necessary in the majority of patients treated with prochlorperazine (16/28) and metoclopramide (23/29) after the 60-minute study period. Although intramuscular prochlorperazine appears to provides more effective relief than metoclopramide, these results do not recommend either drug as single-agent therapy for acute migraine headache. |
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Authors:
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J Jones; S Pack; E Chun |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 14 ISSN: 0735-6757 ISO Abbreviation: Am J Emerg Med Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-07-15 Completed Date: 1996-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 262-4 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Butterworth Hospital, Michigan State University College of Human Medicine, Grand Rapids 49503, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Analgesics, Opioid / therapeutic use Antiemetics / therapeutic use* Double-Blind Method Emergency Service, Hospital Female Humans Injections, Intramuscular Male Metoclopramide / therapeutic use* Migraine Disorders / drug therapy* Pain Measurement Prochlorperazine / therapeutic use* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Antiemetics; 364-62-5/Metoclopramide; 58-38-8/Prochlorperazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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