| Intramuscular pressures with limb compression clarification of the pathogenesis of the drug-induced muscle-compartment syndrome. | |
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MedLine Citation:
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PMID: 431646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study muscle necrosis due to prolonged limb compression, we measured intramuscular pressure by inserting wick catheters into 10 volar forearms and 10 anterior tibial compartments of adult volunteers. We then placed the subjects in positions in which victims of drug overdose are commonly found. Intramuscular pressures in the area of direct compression on hard surfaces ranged from 26 to 240 mm Hg, and averaged 101 mm Hg. Most remarkable was a mean pressure of 180 mm Hg on compression of the forearm by the rib cage. These pressures are sufficient to cause muscle and capillary ischemia and necrosis by local obstruction of the circulation. This local injury by limb compression may produce edema sufficient to start compartment tamponade and consequent muscle-compartment and crush syndromes. |
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Authors:
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C A Owen; S J Mubarak; A R Hargens; L Rutherford; L P Garetto; W H Akeson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 300 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1979 May |
Date Detail:
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Created Date: 1979-06-29 Completed Date: 1979-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1169-72 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anterior Compartment Syndrome / etiology Catheterization / methods Crush Syndrome / etiology* Edema / etiology Extracellular Space / physiology* Extremities / blood supply* Female Forearm / blood supply Humans Immobilization Ischemia / etiology*, physiopathology Leg / blood supply Male Muscles / blood supply, physiology* Muscular Diseases / etiology*, physiopathology Necrosis Posture Pressure Shock, Traumatic / etiology* Substance-Related Disorders / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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