Document Detail

Intramuscular pressures with limb compression clarification of the pathogenesis of the drug-induced muscle-compartment syndrome.
MedLine Citation:
PMID:  431646     Owner:  NLM     Status:  MEDLINE    
To study muscle necrosis due to prolonged limb compression, we measured intramuscular pressure by inserting wick catheters into 10 volar forearms and 10 anterior tibial compartments of adult volunteers. We then placed the subjects in positions in which victims of drug overdose are commonly found. Intramuscular pressures in the area of direct compression on hard surfaces ranged from 26 to 240 mm Hg, and averaged 101 mm Hg. Most remarkable was a mean pressure of 180 mm Hg on compression of the forearm by the rib cage. These pressures are sufficient to cause muscle and capillary ischemia and necrosis by local obstruction of the circulation. This local injury by limb compression may produce edema sufficient to start compartment tamponade and consequent muscle-compartment and crush syndromes.
C A Owen; S J Mubarak; A R Hargens; L Rutherford; L P Garetto; W H Akeson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  300     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1169-72     Citation Subset:  AIM; IM; S    
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MeSH Terms
Anterior Compartment Syndrome / etiology
Catheterization / methods
Crush Syndrome / etiology*
Edema / etiology
Extracellular Space / physiology*
Extremities / blood supply*
Forearm / blood supply
Ischemia / etiology*,  physiopathology
Leg / blood supply
Muscles / blood supply,  physiology*
Muscular Diseases / etiology*,  physiopathology
Shock, Traumatic / etiology*
Substance-Related Disorders / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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