Document Detail

Intramuscular fetal corticosteroid therapy: short-term effects on the fetus.
MedLine Citation:
PMID:  19246927     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to assess the short-term effects of direct intramuscular (i.m.) corticosteroid therapy on fetal biophysical profile, baseline fetal heart rate and the nonstress test, which indicate the degree of fetal hypoxia. METHOD: We evaluated the effect of direct i.m. fetal single-dose dexamethasone (4 mg/kg) on the fetal biophysical profile 2 h before and 2-4 h after corticosteroid therapy in 41 fetuses in the 32nd week of gestation at risk of preterm delivery. Risk factors for preterm delivery included pregnancy-induced hypertension and preeclampsia. RESULT: There was a statistically significant difference between fetal breathing movements before and after corticosteroid therapy (p = 0.019; 95% confidence interval for difference -11.75, -1.12). No significant changes were observed between baseline fetal heart rate before and after corticosteroid therapy (p = 0.99; 95% confidence interval for difference -4.81, +4.81), biophysical profile before and after fetal corticosteroid therapy, p = 0.235 as well as the nonstress test before and after therapy (p = 0.564). CONCLUSION: Direct corticosteroid i.m. fetal therapy results in increasing profound short-term fetal breathing movements. There are no changes in baseline fetal heart rate, biophysical profile score, and nonstress test.
I Babovic; S Plesinac; J Opalic; V Devrnja; I Pavlovic; Z Radojicic; D Plecas; N Radunovic; A Ljubic
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Publication Detail:
Type:  Journal Article     Date:  2009-02-25
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia.
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MeSH Terms
Dexamethasone / administration & dosage,  adverse effects*
Fetal Hypoxia / chemically induced*
Fetus / drug effects*
Glucocorticoids / administration & dosage,  adverse effects*
Heart Rate, Fetal / drug effects*
Injections, Intramuscular
Respiration / drug effects
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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