| Intramuscular fetal corticosteroid therapy: short-term effects on the fetus. | |
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MedLine Citation:
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PMID: 19246927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to assess the short-term effects of direct intramuscular (i.m.) corticosteroid therapy on fetal biophysical profile, baseline fetal heart rate and the nonstress test, which indicate the degree of fetal hypoxia. METHOD: We evaluated the effect of direct i.m. fetal single-dose dexamethasone (4 mg/kg) on the fetal biophysical profile 2 h before and 2-4 h after corticosteroid therapy in 41 fetuses in the 32nd week of gestation at risk of preterm delivery. Risk factors for preterm delivery included pregnancy-induced hypertension and preeclampsia. RESULT: There was a statistically significant difference between fetal breathing movements before and after corticosteroid therapy (p = 0.019; 95% confidence interval for difference -11.75, -1.12). No significant changes were observed between baseline fetal heart rate before and after corticosteroid therapy (p = 0.99; 95% confidence interval for difference -4.81, +4.81), biophysical profile before and after fetal corticosteroid therapy, p = 0.235 as well as the nonstress test before and after therapy (p = 0.564). CONCLUSION: Direct corticosteroid i.m. fetal therapy results in increasing profound short-term fetal breathing movements. There are no changes in baseline fetal heart rate, biophysical profile score, and nonstress test. |
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Authors:
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I Babovic; S Plesinac; J Opalic; V Devrnja; I Pavlovic; Z Radojicic; D Plecas; N Radunovic; A Ljubic |
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Publication Detail:
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Type: Journal Article Date: 2009-02-25 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 25 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: IM |
Copyright Information:
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(c) 2009 S. Karger AG, Basel. |
Affiliation:
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Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia. plesinac@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dexamethasone / administration & dosage, adverse effects* Female Fetal Hypoxia / chemically induced* Fetus / drug effects* Glucocorticoids / administration & dosage, adverse effects* Heart Rate, Fetal / drug effects* Humans Injections, Intramuscular Pregnancy Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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