| Intramuscular depot methylprednisolone induction of chrysotherapy in rheumatoid arthritis: a 24-week randomized controlled trial. | |
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MedLine Citation:
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PMID: 2198977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-nine patients commencing intramuscular sodium aurothiomalate therapy were randomized to receive three doses of 120 mg intramuscular depot methylprednisolone acetate or matching placebo at weeks 0, 4, and 8 in addition to chrysotherapy. The group receiving methylprednisolone had more rapid disease improvement. This advantage persisted for up to 12 weeks, although by 24 weeks both groups exhibited similar benefits due to continued improvement in the group treated with gold alone. Withdrawals secondary to gold-induced side-effects occurred later in the steroid group (median time to withdrawal: 15 weeks steroid; 4.5 weeks placebo, P less than 0.05), and there were fewer withdrawals due to a lack of effect in the steroid group (one steroid versus three placebo, P NS). We conclude that glucocorticoids given as intermittent, intramuscular depot injections have a significant short term benefit which can be maintained by concomitant administration of intramuscular gold. |
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Authors:
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M M Corkill; B W Kirkham; I C Chikanza; T Gibson; G S Panayi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 29 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-09-13 Completed Date: 1990-09-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 274-9 Citation Subset: AIM; IM |
Affiliation:
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Rheumatology Unit, United Medical School, Guy's Hospital, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Arthritis, Rheumatoid / blood, drug therapy*, pathology Arthrography Blood Sedimentation Delayed-Action Preparations Female Gold / administration & dosage, adverse effects, therapeutic use* Hemoglobins / analysis Humans Injections, Intramuscular Joints / pathology Male Methylprednisolone / administration & dosage*, adverse effects, therapeutic use Middle Aged Randomized Controlled Trials as Topic Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Hemoglobins; 7440-57-5/Gold; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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