Document Detail

Intramuscular depot methylprednisolone induction of chrysotherapy in rheumatoid arthritis: a 24-week randomized controlled trial.
MedLine Citation:
PMID:  2198977     Owner:  NLM     Status:  MEDLINE    
Fifty-nine patients commencing intramuscular sodium aurothiomalate therapy were randomized to receive three doses of 120 mg intramuscular depot methylprednisolone acetate or matching placebo at weeks 0, 4, and 8 in addition to chrysotherapy. The group receiving methylprednisolone had more rapid disease improvement. This advantage persisted for up to 12 weeks, although by 24 weeks both groups exhibited similar benefits due to continued improvement in the group treated with gold alone. Withdrawals secondary to gold-induced side-effects occurred later in the steroid group (median time to withdrawal: 15 weeks steroid; 4.5 weeks placebo, P less than 0.05), and there were fewer withdrawals due to a lack of effect in the steroid group (one steroid versus three placebo, P NS). We conclude that glucocorticoids given as intermittent, intramuscular depot injections have a significant short term benefit which can be maintained by concomitant administration of intramuscular gold.
M M Corkill; B W Kirkham; I C Chikanza; T Gibson; G S Panayi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  29     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  274-9     Citation Subset:  AIM; IM    
Rheumatology Unit, United Medical School, Guy's Hospital, London.
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MeSH Terms
Arthritis, Rheumatoid / blood,  drug therapy*,  pathology
Blood Sedimentation
Delayed-Action Preparations
Gold / administration & dosage,  adverse effects,  therapeutic use*
Hemoglobins / analysis
Injections, Intramuscular
Joints / pathology
Methylprednisolone / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Randomized Controlled Trials as Topic
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Hemoglobins; 7440-57-5/Gold; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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