Document Detail


Intramuscular administration of salmon calcitonin impairs delayed cutaneous hypersensitivity.
MedLine Citation:
PMID:  3191274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The delayed cutaneous hypersensitivity to seven ubiquitous antigens (Multitest CMI, Istitute Mĕrieux) was evaluated in normal healthy volunteers before and at the time of intramuscular administration of 50 (12 subjects) or 50 + 50 (nine subjects) units of salmon calcitonin or 2 ml of saline (eight subjects). The delayed cutaneous hypersensitivity, in terms of number of positive tests or sum of positive tests, significantly fell in both groups given salmon calcitonin, but no changes were observed in the control group. These results indicate that salmon calcitonin, as well as inhibiting osteoclastic bone resorption, has important immunological effects.
Authors:
S Adami; R Suppi; M Residori; V Braga; M Zamboni; V LoCascio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone and mineral     Volume:  4     ISSN:  0169-6009     ISO Abbreviation:  Bone Miner     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1989-01-09     Completed Date:  1989-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610542     Medline TA:  Bone Miner     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
Affiliation:
Istituto di Semeiotica e Nefrologia Medica, University of Verona, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcitonin / pharmacology*
Female
Humans
Hypersensitivity, Delayed*
Immunity, Cellular / drug effects*
Male
Middle Aged
Chemical
Reg. No./Substance:
47931-85-1/salmon calcitonin; 9007-12-9/Calcitonin

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