Document Detail


Intramuscular adipose tissue and central activation in older adults.
MedLine Citation:
PMID:  23055318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Intramuscular adipose tissue (IMAT) is a potential contributor to declining force production and may be related to impaired central activation; therefore, the purpose of this report is to describe IMAT composition and its association with central activation in older adults. The central activation ratio (CAR) of the knee extensors was assessed using a superimposition technique in 15 older adults (29 legs) along with the cross-sectional area of IMAT and lean tissue.
RESULTS: IMAT and CAR are inversely related in older adults (r = -0.51, P = 0.005), and many subjects with high IMAT have deficits in central activation, whereas those with low IMAT have normal central activation.
CONCLUSIONS: These novel findings may assist in unraveling why muscle force production and lean tissue cross-sectional area are not strongly linked, as the ability to centrally activate muscle appears to be unrelated to lean muscle area and may be dependent in part on IMAT levels.
Authors:
Yuri Yoshida; Robin L Marcus; Paul C Lastayo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Muscle & nerve     Volume:  46     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2012-12-18     Revised Date:  2013-06-19    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake City, Utah 84108, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology*
Aged
Aged, 80 and over
Aging / physiology*
Body Composition / physiology
Female
Humans
Isometric Contraction / physiology*
Male
Middle Aged
Muscle, Skeletal / physiology*
Grant Support
ID/Acronym/Agency:
K12 HD043449/HD/NICHD NIH HHS; R01 AG031255/AG/NIA NIH HHS; R01 DK064814/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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