| Intramural delivery of bortezomib inhibits restenosis following arterial injury. | |
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MedLine Citation:
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PMID: 22090177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Background: Several studies have demonstrated that the proteasome inhibitors prevent restenosis following arterial injury. The proteasome inhibitor bortezomib shows anti-inflammatory and antiproliferative effects. Here, we evaluate the efficacy of bortezomib in inhibiting the restenosis following arterial injury and the effect on nuclear factor kappa B (NF-kappaB) and p27. Methods: An injured iliac artery rabbit model was established by balloon over-stretching. Rabbits were intramurally infused with bortezomib or normal saline by a transport coronary dilatation catheter in the bortezomib (n = 20) or control (n = 20) groups, respectively, and they were sacrificed on the 7th or 21th day following the arterial injury. Neointimal area was measured by computer analysis of photomicrographs, while expression of NF-kappaB and of p27 on day 7 were evaluated by Western blotting and immunohistochemistry, respectively. Results: Expression of p27 (56.10 ± 3.03% vs. 10.24 ± 0.60%, p < 0.05) was significantly higher while that of NF-kappaB (0.44 ± 0.02 vs. 0.70 ± 0.03, p < 0.05) was significantly lower in the bortezomib group than in control group on day 7 after arterial injury. Neointimal formation was significantly lower in the bortezomib group on day 21 after arterial injury (0.67 ± 0.03 vs. 1.30 ± 0.05 intima/media ratio, p < 0.05). Conclusions: Intramural delivery of bortezomib reduces neointimal formation, possibly via a mechanism involving upregulation of the p27 and downregulation of the NF-kappaB. Bortezomib therefore may be an alternative therapeutic approach for preventing restenosis. |
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Authors:
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X Gong; Y Zhou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: VASA. Zeitschrift für Gefässkrankheiten Volume: 40 ISSN: 0301-1526 ISO Abbreviation: VASA Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: 2012-01-31 Revised Date: 2012-10-19 |
Medline Journal Info:
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Nlm Unique ID: 0317051 Medline TA: Vasa Country: Switzerland |
Other Details:
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Languages: eng Pagination: 449-52 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Capital Medical University, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Boronic Acids / pharmacology* Constriction, Pathologic / pathology Cyclin-Dependent Kinase Inhibitor p27 / analysis Down-Regulation / drug effects Iliac Artery / drug effects*, injuries*, pathology Immunoenzyme Techniques Male Muscle, Smooth, Vascular / drug effects, pathology NF-kappa B / analysis Neointima / pathology* Protease Inhibitors / pharmacology* Proteasome Endopeptidase Complex / antagonists & inhibitors* Pyrazines / pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/NF-kappa B; 0/Protease Inhibitors; 0/Pyrazines; 0/bortezomib; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 3.4.25.1/Proteasome Endopeptidase Complex |
| Comments/Corrections | |
Comment In:
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Vasa. 2011 Nov;40(6):425-6
[PMID:
22191123
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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