Document Detail


Intramural delivery of bortezomib inhibits restenosis following arterial injury.
MedLine Citation:
PMID:  22090177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Background: Several studies have demonstrated that the proteasome inhibitors prevent restenosis following arterial injury. The proteasome inhibitor bortezomib shows anti-inflammatory and antiproliferative effects. Here, we evaluate the efficacy of bortezomib in inhibiting the restenosis following arterial injury and the effect on nuclear factor kappa B (NF-kappaB) and p27. Methods: An injured iliac artery rabbit model was established by balloon over-stretching. Rabbits were intramurally infused with bortezomib or normal saline by a transport coronary dilatation catheter in the bortezomib (n = 20) or control (n = 20) groups, respectively, and they were sacrificed on the 7th or 21th day following the arterial injury. Neointimal area was measured by computer analysis of photomicrographs, while expression of NF-kappaB and of p27 on day 7 were evaluated by Western blotting and immunohistochemistry, respectively. Results: Expression of p27 (56.10 ± 3.03% vs. 10.24 ± 0.60%, p < 0.05) was significantly higher while that of NF-kappaB (0.44 ± 0.02 vs. 0.70 ± 0.03, p < 0.05) was significantly lower in the bortezomib group than in control group on day 7 after arterial injury. Neointimal formation was significantly lower in the bortezomib group on day 21 after arterial injury (0.67 ± 0.03 vs. 1.30 ± 0.05 intima/media ratio, p < 0.05). Conclusions: Intramural delivery of bortezomib reduces neointimal formation, possibly via a mechanism involving upregulation of the p27 and downregulation of the NF-kappaB. Bortezomib therefore may be an alternative therapeutic approach for preventing restenosis.
Authors:
X Gong; Y Zhou
Related Documents :
11894047 - Imaging of endoleaks.
23842727 - Fenestrated vertebral artery.
24851007 - Bilateral asymmetrical duplicated origin of vertebral arteries: multidetector row ct an...
19364727 - Femoral arterial access management for endovascular aortic aneurysm repair: evolution a...
3791607 - Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo...
21968317 - Imaging of the carotid artery.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  40     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-01-31     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Capital Medical University, Beijing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Boronic Acids / pharmacology*
Constriction, Pathologic / pathology
Cyclin-Dependent Kinase Inhibitor p27 / analysis
Down-Regulation / drug effects
Iliac Artery / drug effects*,  injuries*,  pathology
Immunoenzyme Techniques
Male
Muscle, Smooth, Vascular / drug effects,  pathology
NF-kappa B / analysis
Neointima / pathology*
Protease Inhibitors / pharmacology*
Proteasome Endopeptidase Complex / antagonists & inhibitors*
Pyrazines / pharmacology*
Rabbits
Chemical
Reg. No./Substance:
0/Boronic Acids; 0/NF-kappa B; 0/Protease Inhibitors; 0/Pyrazines; 0/bortezomib; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections
Comment In:
Vasa. 2011 Nov;40(6):425-6   [PMID:  22191123 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vascular anomalies in children.
Next Document:  Patient specific biomodel of the whole aorta - the importance of calcified plaque removal.