| Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams. | |
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MedLine Citation:
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PMID: 17880098 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Functionalized gem-difluoro beta- and gamma-lactams were synthesized through a novel intramolecular hydroamination reaction of difluoropropargyl amides. beta-Lactams were obtained via a Baldwin disfavored 4-exo-digonal cyclization using palladium acetate as the catalyst, whereas gamma-lactams were produced under basic conditions. Acid hydration of gamma-lactams produced ketoamides or hemiaminals selectively. |
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Authors:
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Santos Fustero; Begoña Fernández; Paula Bello; Carlos Del Pozo; Satoru Arimitsu; Gerald B Hammond |
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Publication Detail:
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Type: Journal Article Date: 2007-09-19 |
Journal Detail:
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Title: Organic letters Volume: 9 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-04 Completed Date: 2007-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 4251-3 Citation Subset: - |
Affiliation:
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Departamento de Química OrgAnica, Universidad de Valencia, E-46100 Burjassot, Spain. santos.fustero@uv.es |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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