| Intramolecular hydroamination of alkynes catalyzed by Pd(PPh3)4/triphenylphosphine under neutral conditions. | |
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MedLine Citation:
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PMID: 15932337 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The intramolecular hydroamination of alkynes tethered with amino group 1 in the presence of catalytic amounts of Pd(PPh3)4 and PPh3 in benzene at 100 degrees C proceeded smoothly without the use of any additional acid source to afford five- and six-membered nitrogen heterocycles 2 in good to excellent yields. A compulsory addition of carboxylic acid as a cocatalyst was not needed, and the reaction could be carried out under essentially neutral conditions. |
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Authors:
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Gan B Bajracharya; Zhibao Huo; Yoshinori Yamamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 70 ISSN: 0022-3263 ISO Abbreviation: J. Org. Chem. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-03 Completed Date: 2005-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 4883-6 Citation Subset: - |
Affiliation:
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Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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