Document Detail


Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.
MedLine Citation:
PMID:  20945849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.
Authors:
Hai-Chao Xu; Kevin D Moeller
Related Documents :
3605599 - 4'-[aminomethyl]fluorescein and its n-alkyl derivatives: useful reagents in immunodiagn...
11674139 - A novel class of conformationally constrained, masked cysteines: synthesis of 2-alkyl- ...
12565949 - Synthesis and antitumor activity of novel c-8 ester derivatives of leinamycin.
15950039 - Comprehensive characterization of oil refinery effluent-derived humic substances using ...
16643039 - Bioactivity profiling using hplc/microtiter-plate analysis: application to a new zealan...
8885369 - Thermospray mass spectral analyses of corynomycolic acids and their derivatives.
19700039 - Docosahexaenoic acid and eicosapentaenoic acid affect ovarian prostaglandin levels diff...
20091239 - Two new triterpenoid saponins from rhizome of anemone raddeana regel.
8024599 - Peroxisomal acyl-coenzyme a oxidase is a rate-limiting enzyme in a very-long-chain fatt...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-10-14
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2011-01-14     Revised Date:  2014-04-23    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5174-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetals / chemistry
Amination
Amino Acids, Cyclic / chemical synthesis*,  chemistry
Catalysis
Combinatorial Chemistry Techniques
Organometallic Compounds / chemistry
Pipecolic Acids / chemical synthesis*,  chemistry
Proline / analogs & derivatives,  chemical synthesis*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
P41 GM103422/GM/NIGMS NIH HHS; P41 RR000954/RR/NCRR NIH HHS; RR00954/RR/NCRR NIH HHS; RR02004/RR/NCRR NIH HHS; RR05018/RR/NCRR NIH HHS; RR07155/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Acetals; 0/Amino Acids, Cyclic; 0/Organometallic Compounds; 0/Pipecolic Acids; 0/n-butyllithium; 535-75-1/pipecolic acid; 9DLQ4CIU6V/Proline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Raman scattering at pure graphene zigzag edges.
Next Document:  Catalytic acylation of amines with aldehydes or aldoximes.