Document Detail

Intramolecular charge transfer effects on flutamide drug.
MedLine Citation:
PMID:  20217464     Owner:  NLM     Status:  MEDLINE    
Spectral characteristics of flutamide drug have been studied in various solvents and beta-cyclodextrin (beta-CD). The inclusion complex of flutamide with beta-CD is analysed by UV-visible, fluorimetry, FT-IR, 1H NMR, SEM, DSC and AM1 methods. In all solvents, flutamide exhibits a dual fluorescence. The longer wavelength emission (A band approximately 380 nm) is due to intramolecular charge transfer state (ICT) and the shorter wavelength emission (B band approximately 285 nm) originates from a locally excited state. In beta-CD, the increase in the fluorescence intensity of 'A' band indicates ICT emission enhanced in the beta-CD medium. beta-CD studies shows isopropyl group is present in the interior part of the beta-CD cavity whereas amino and CF(3) groups are present in the outside of the beta-CD cavity. A mechanism is proposed to explain the 1:1 inclusion process.
A Anton Smith; R Manavalan; K Kannan; N Rajendiran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-10
Journal Detail:
Title:  Journal of fluorescence     Volume:  20     ISSN:  1573-4994     ISO Abbreviation:  J Fluoresc     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201341     Medline TA:  J Fluoresc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  809-20     Citation Subset:  IM    
Department of Pharmacy, Annamalai University, Annamalai nagar, 608 002, Tamilnadu, India.
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MeSH Terms
Calorimetry, Differential Scanning
Chemical Precipitation
Flutamide / chemistry*
Microscopy, Electron, Scanning
Models, Molecular
Molecular Conformation
Solvents / chemistry
Spectrum Analysis
beta-Cyclodextrins / chemistry
Reg. No./Substance:
0/Solvents; 0/beta-Cyclodextrins; 13311-84-7/Flutamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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