| Intramedullary multiple hematomas in siblings with congenital alpha-2-plasmin inhibitor deficiency: orthopedic surgery with protection by tranexamic acid. | |
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MedLine Citation:
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PMID: 1806461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital alpha 2-plasmin inhibitor deficiency is very rare, but causes bleeding problems similar to hemophilia. Three young Japanese sisters affected with congenital alpha 2-plasmin inhibitor deficiency have been reported by us earlier. Recently we encountered a particular form of intramedullary multiple hematomas in the long bones in all of them which was not reported previously. In 2 of the sisters orthopedic operations were successfully performed by using an antiplasmin reagent: tranexamic acid. In this paper we describe the characteristics of the hematomas and the hemostatic management with tranexamic acid. |
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Authors:
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Y Takahashi; T Tanaka; N Nakajima; A Yoshioka; H Fukui; Y Miyauchi; Y Mii; S Tamai |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Haemostasis Volume: 21 ISSN: 0301-0147 ISO Abbreviation: Haemostasis Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-13 Completed Date: 1992-05-13 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0371574 Medline TA: Haemostasis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nara Medical College, Kashihara, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Loss, Surgical / prevention & control* Bone Diseases / etiology*, radiography, surgery Child Female Femur Hematoma / etiology*, radiography, surgery Humans Humerus Radius Tranexamic Acid / therapeutic use* alpha-2-Antiplasmin / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/alpha-2-Antiplasmin; 1197-18-8/Tranexamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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