Document Detail


Intraluminal thrombus enhances proteolysis in abdominal aortic aneurysms.
MedLine Citation:
PMID:  16849017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined whether intraluminal thrombus in abdominal aortic aneurysms (AAAs) is a source of fibrinolytic activity and proteolysis that could weaken the aneurysm wall. Plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) activity, plasminogen activator inhibitor 1 (PAI-1), and alpha2-antiplasmin (alpha2AP) antigen were measured in the AAA wall and juxtamural and luminal aspects of intraluminal thrombus in 18 patients. The aneurysm wall contained 100-fold higher tPA activity (1.06 +/- 0.34 [standard error of measurement] U/mg soluble protein) compared with juxtamural thrombus (JMT) (0.011 +/- 0.001 ) and luminal thrombus (LT) (0.01 +/- 0.001) (p < .00001) and over 6-fold higher uPA activity (29.3 +/- 3.4 IU/mg compared with the JMT (4.3 +/- 2.4, p = .00024) and LT (7.9 +/- 1.76, p = .0005). The LT had significantly lower levels of PAI-1 (1.26 +/- 0.34 ng/mg) than the AAA wall (2.08 +/- 0.51, p = .04) and the JMT (3.94 +/- 0.85, p = .007). The levels of alpha2AP in the wall (19.4 +/- 3.1 ng/mg) were lower than in the JMT or LT (43.0 +/- 7.9 ng/mg, p = .013, and 47.6 +/- 6.0 ng/mg, p = .002, respectively). There was no significant difference, however, in plasmin activity among the AAA wall, JMT, and LT. There were significant amounts of latent gelatinase B (matrix metalloproteinase [MMP]-9) in the AAA, JMT, and LT. Mean levels of activated MMP-9 activity were similar in the AAA, JMT, and LT. Plasmin activation of MMPs at the interface between intraluminal thrombus and the aneurysm wall may enhance proteolysis and accelerate aneurysm expansion.
Authors:
Tom W G Carrell; Kevin G Burnand; Nuala A Booth; Julia Humphries; Alberto Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vascular     Volume:  14     ISSN:  1708-5381     ISO Abbreviation:  Vascular     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-08-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101196722     Medline TA:  Vascular     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  9-16     Citation Subset:  IM    
Affiliation:
Academic Department of Surgery, King's College London, St Thomas' Hospital, London, United Kingdom. Tom.Carrell@gstt.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal / complications*,  metabolism,  pathology
Enzyme Activation
Female
Fibrinolysin / analysis
Fibrinolysis
Humans
Male
Middle Aged
Peptide Hydrolases / metabolism*
Plasminogen Activator Inhibitor 1 / analysis
Thrombosis / complications*,  enzymology,  metabolism
Tissue Plasminogen Activator / analysis
Urokinase-Type Plasminogen Activator / analysis
alpha-2-Antiplasmin / analysis
Chemical
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 0/alpha-2-Antiplasmin; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.7/Fibrinolysin; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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