| Intraluminal papaverine with pH 3 doubles blood flow in the internal mammary artery. | |
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MedLine Citation:
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PMID: 10622543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy-five patients undergoing coronary artery bypass grafting were randomized to receive injections of papaverine solution or isotonic saline or no injection into the left internal mammary artery (LIMA) used as graft. Blood flow in the LIMA was measured twice-after dissection of the pedicle and before anastomosis to the coronary artery. Blood flow increased significantly in all three groups, but after papaverine injection it was twice as high as in the control groups, increasing by 285% (from 40 +/- 12 to 154 +/- 32 ml/min, p = < 0.0001). The pH of the papaverine solution was only 3, and we advise that surgeons check and correct pH in the papaverine solutions they use, in order to avoid endothelial damage to the LIMA. Based on these results we can recommend papaverine injection into the arterial graft only if the initial flow is low. |
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Authors:
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J Vilandt; H Kjaergård; S Aggestrup; J J Andreasen; A Olesen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 33 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-01-24 Completed Date: 2000-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: NORWAY |
Other Details:
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Languages: eng Pagination: 330-2 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Gentofte Hospital, University of Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity / drug effects Coronary Artery Bypass Female Humans Hydrogen-Ion Concentration Injections, Intra-Arterial Male Mammary Arteries / drug effects, physiology*, transplantation Middle Aged Papaverine / administration & dosage* Treatment Outcome Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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