Document Detail

Intraluminal modulation of gastric sensitivity to distension: effects of hydrochloric acid and meal.
MedLine Citation:
PMID:  11292599     Owner:  NLM     Status:  MEDLINE    
Conscious sensations in response to gut distensions may be modulated by temporospatial interactions among different stimuli. This study investigated whether symptoms induced by gastric distension may be modified by hydrochloric acid (HCl) gastric infusion and meal ingestion. In nine healthy subjects, fixed pressure (isobaric) and fixed volume (isovolumetric) distensions were performed during continuous (4 ml/min) intragastric saline or HCl infusion, during fasting and after meal ingestion, until the maximal distension step defined as discomfort or a predefined maximal volume. During fasting isobaric distensions, the maximal distension step was significantly decreased during HCl compared with saline. The intragastric volumes were not significantly different, but the wall tension was significantly lower during HCl than saline. HCl increased gastric compliance. Meal ingestion relaxed the stomach and decreased the pressure at the maximal distension step during saline, but HCl did not further decrease it compared with fasting. During isovolumetric distensions, HCl also increased gastric compliance, but in both fasted and fed states it did not modify the maximal distension steps. In conclusion, sensations in response to gastric isobaric distensions, but not to isovolumetric distensions, are influenced by gastric acid infusion and meal ingestion. The effects of HCl might be related to a sensitization of mucosal mechanoreceptors.
B Coffin; R Chollet; B Flourié; M Lémann; C Franchisseur; J C Rambaud; R Jian
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  280     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-09     Completed Date:  2001-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G904-9     Citation Subset:  IM    
Gastroenterology Unit, Louis Mourier Hospital, 178 Rue des Renouillers, 92701 Colombes Cedex, France.
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MeSH Terms
Digestion / physiology*
Eating / physiology*
Fasting / physiology
Hydrochloric Acid / administration & dosage,  pharmacology*
Infusions, Parenteral
Postprandial Period / physiology*
Reference Values
Stomach / drug effects,  physiology*
Reg. No./Substance:
7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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