| Intralipid increases lung polyunsaturated fatty acids and protects newborn rats from oxygen toxicity. | |
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MedLine Citation:
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PMID: 1754294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intralipid, derived from soybean oil and containing a high percentage of n-6 family polyunsaturated fatty acids (PUFA) and also linolenic acid, an n-3 family PUFA, is commonly the first fat source provided to very low birth weight premature infants. Following up on our previous reports that newborn rats born to dams fed high-PUFA diets demonstrate superior tolerance to hyperoxia, we examined whether the high-PUFA fat source Intralipid might also protect against oxygen toxicity. Adult female rats were fed either regular Rat Chow or fat-free diet containing 20%-Intralipid as the fat source for 3 wk before and then throughout pregnancy and lactation. One- and 5-d-old offspring of Intralipid diet-fed dams demonstrated significant increases in lung lipid n-6 family PUFA plus elevated linolenic acid compared with regular diet-fed offspring. These characteristic fatty acid patterns, apparent in total lung lipids, were even more pronounced in the triglyceride fraction compared with the phospholipid fraction. Associated with these fatty acid changes were significantly improved hyperoxic survival rates (89 out of 95 = 94% survival after 7 d of greater than 95% O2 exposure) in Intralipid offspring (versus 89 out of 106 = 84%, p less than 0.05 in regular diet offspring) and evidence of superior clinical/pathologic status. No differences in pulmonary antioxidant enzyme or surfactant system development, response of antioxidant enzymes to hyperoxic exposure, or lung prostaglandin E2, 6-keto PGF1-alpha or leukotrienes C4-F4 were present. These findings continue to support the hypothesis that increasing lung PUFA content may provide increased O2 free radical scavenging capacity, thus protecting against hyperoxic lung damage.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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I R Sosenko; S M Innis; L Frank |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 30 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-27 Completed Date: 1992-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 413-7 Citation Subset: IM |
Affiliation:
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Calvin and Flavia Oak Asthma Research Facility, Department of Pediatrics, University of Miami School of Medicine, Florida 33101. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Dietary Fats / administration & dosage Fat Emulsions, Intravenous / administration & dosage, pharmacology* Fatty Acids, Unsaturated / metabolism* Female Lung / drug effects*, metabolism Oxygen / toxicity* Pregnancy Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Unsaturated; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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